ArticleScientific reports2016
Cu isotopic signature in blood serum of liver transplant patients: a follow-up study.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 60 citations in OpenAlex.
- Copper isotope fractionation and copper-to-zinc ratios reveal altered metal homeostasis in prostate cancer.Scientific reports · 2026Article
- Six transmembrane epithelial antigens of the prostate to illustrate inflammatory response in gastrointestinal cancers.World journal of clinical oncology · 2024Article
- Impact of aging on copper isotopic composition in the murine brain.Metallomics : integrated biometal science · 2024Article
- Inflammatory response in gastrointestinal cancers: Overview of six transmembrane epithelial antigens of the prostate in pathophysiology and clinical implications.World journal of clinical oncology · 2024Review
- Dysregulation of Copper Metabolism in a Patient With Acute-on-Chronic Liver Failure Worked up for Fulminant Wilson Disease.ACG case reports journal · 2023Article
- Alzheimer's Disease and Age-Related Changes in the Cu Isotopic Composition of Blood Plasma and Brain Tissues of the APPBiology · 2023Article
- Identification of two-dimensional copper signatures in human blood for bladder cancer with machine learning.Chemical science · 2022Article
- Copper Isotope Evidence of Oxidative Stress-Induced Hepatic Breakdown and the Transition to Hepatocellular Carcinoma.Gastro hep advances · 2022Article
- Homeostatic alterations related to total antioxidant capacity, elemental concentrations and isotopic compositions in aqueous humor of glaucoma patients.Analytical and bioanalytical chemistry · 2022Article
- Iron Isotopic Composition of Biological Standards Relevant to Medical and Biological Applications.Frontiers in medicine · 2021Article
- Lighter serum copper isotopic composition in patients with early non-alcoholic fatty liver disease.BMC research notes · 2020Article
- Copper and zinc isotopic excursions in the human brain affected by Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Serum and brain natural copper stable isotopes in a mouse model of Alzheimer's disease.Scientific reports · 2019Article
- Impact of uranium uptake on isotopic fractionation and endogenous element homeostasis in human neuron-like cells.Scientific reports · 2018Article
- Cu, Fe, and Zn isotope ratios in murine Alzheimer's disease models suggest specific signatures of amyloidogenesis and tauopathy.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
End-stage liver disease (ESLD) is life-threatening and liver transplantation (LTx) is the definitive treatment with good outcomes. Given the essential role of hepatocytes in Cu homeostasis, the potential of the serum Cu isotopic composition for monitoring a patient's condition post-LTx was evaluated. For this purpose, high-precision Cu isotopic analysis of blood serum of ESLD patients pre- and post-LTx was accomplished via multi-collector ICP-mass spectrometry (MC-ICP-MS). The Cu isotopic composition of the ESLD patients was fractionated in favour of the lighter isotope (by about -0.50‰). Post-LTx, a generalized normalization of the Cu isotopic composition was observed for the patients with normal liver function, while it remained light when this condition was not reached. A strong decrease in the δ(65)Cu value a longer term post-LTx seems to indicate the recurrence of liver failure or cancer. The observed trend in favour of the heavier Cu isotopic composition post-LTx seems to be related with the restored biosynthetic capacity of the liver, the restored hepatic metabolism and/or the restored biliary secretion pathways. Thus, Cu isotopic analysis could be a valuable tool for the follow-up of liver transplant patients and for establishing the potential recurrence of liver failure.
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