ArticleThe Journal of infectious diseases2016
Effect of Statin Use on Influenza Vaccine Effectiveness.
Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Medication count, including statin or metformin use, is not associated with influenza vaccine responses in older adults.Vaccine · 2025Trial
- Immune Consequences of Metabolic Syndrome and Its Treatment: A Cytokine Perspective.Immunology · 2026Article
- Evaluating the Impact of Statin Use on Influenza Vaccine Effectiveness and Influenza Infection in Older Adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- A pilot metabolomic study of drug interaction with the immune response to seasonal influenza vaccination.NPJ vaccines · 2023Article
- Article
- Risk of waning humoral responses after inactivated or subunit recombinant SARS-CoV-2 vaccination in patients with chronic diseases: Findings from a prospective observational study in China.Journal of medical virology · 2023Observational
- The effect of statins on the prevalence and mortality of influenza virus infection: a systematic review and meta-analysis.Archives of medical science : AMS · 2022Review
- Article
- Epigenetic susceptibility to severe respiratory viral infections and its therapeutic implications: a narrative review.British journal of anaesthesia · 2020Review
- Clinical practice guidelines 2019: Indian consensus-based recommendations on influenza vaccination in adults.Lung India : official organ of Indian Chest Society · 2020Article
- Factors Influencing Persistence of Diphtheria Immunity and Immune Response to a Booster Dose in Healthy Slovak Adults.Vaccines · 2019Article
- Influenza Vaccine Effectiveness and Statin Use Among Adults in the United States, 2011-2017.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Observational
- Impact of Dietary Cholesterol on the Pathophysiology of Infectious and Autoimmune Disease.Nutrients · 2018Review
- Immune History and Influenza Vaccine Effectiveness.Vaccines · 2018Review
- Article
- Article
- Immune response to influenza vaccination in the elderly is altered by chronic medication use.Immunity & ageing : I & A · 2018Article
- Healthy elderly Singaporeans show no age-related humoral hyporesponsiveness nor diminished plasmablast generation in response to influenza vaccine.Immunity & ageing : I & A · 2018Article
- Skin immunization by microneedle patch overcomes statin-induced suppression of immune responses to influenza vaccine.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundRecent studies suggest that statin use may reduce influenza vaccine effectiveness (VE), but laboratory-confirmed influenza was not assessed.
methodsPatients ≥45 years old presenting with acute respiratory illness were prospectively enrolled during the 2004-2005 through 2014-2015 influenza seasons. Vaccination and statin use were extracted from electronic records. Respiratory samples were tested for influenza virus.
resultsThe analysis included 3285 adults: 1217 statin nonusers (37%), 903 unvaccinated statin nonusers (27%), 847 vaccinated statin users (26%), and 318 unvaccinated statin users (10%). Statin use modified VE and the risk of influenza A(H3N2) virus infection (P = .002) but not 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) or influenza B virus infection (P = .2 and .4, respectively). VE against influenza A(H3N2) was 45% (95% confidence interval [CI], 27%-59%) among statin nonusers and -21% (95% CI, -84% to 20%) among statin users. Vaccinated statin users had significant protection against influenza A(H1N1)pdm09 (VE, 68%; 95% CI, 19%-87%) and influenza B (VE, 48%; 95% CI, 1%-73%). Statin use did not significantly modify VE when stratified by prior season vaccination. In validation analyses, the use of other cardiovascular medications did not modify influenza VE.
conclusionsStatin use was associated with reduced VE against influenza A(H3N2) but not influenza A(H1N1)pdm09 or influenza B. Further research is needed to assess biologic plausibility and confirm these results.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.