ArticlePloS one2016
Identification of MEF2B and TRHDE Gene Polymorphisms Related to Growth Traits in a New Ujumqin Sheep Population.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 49 citations in OpenAlex.
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- Genome-Wide Analysis for Early Growth-Related Traits of the Locally Adapted Egyptian Barki Sheep.Genes · 2021Article
- Genome-wide association and transcriptome studies identify candidate genes and pathways for feed conversion ratio in pigs.BMC genomics · 2021Article
- Comparative Enhancer Map of Cattle Muscle Genome Annotated by ATAC-Seq.Frontiers in veterinary science · 2021Article
- Comparative population genomic analysis uncovers novel genomic footprints and genes associated with small body size in Chinese pony.BMC genomics · 2020Article
- Genetic analysis of body weight in wild populations of medaka fish from different latitudes.PloS one · 2020Article
- Review on Genomic Regions and Candidate Genes Associated with Economically Important Production and Reproduction Traits in Sheep (Animals : an open access journal from MDPI · 2019Review
- Identification of copy number variations using high density whole-genome SNP markers in Chinese Dongxiang spotted pigs.Asian-Australasian journal of animal sciences · 2019Article
- Recent advances in understanding genetic variants associated with growth, carcass and meat productivity traits in sheep (Archives animal breeding · 2019Article
- Tanycytes and the Control of Thyrotropin-Releasing Hormone Flux Into Portal Capillaries.Frontiers in endocrinology · 2019Review
- Novel insights into the genetic basis of buffalo reproductive performance.BMC genomics · 2018Article
- The distribution of runs of homozygosity and selection signatures in six commercial meat sheep breeds.PloS one · 2017Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
2 SNPs were discovered in our previous genome-wide association study (GWAS): s58995.1 (rs420767326 A>G) in MEF2B gene and OAR3_115712045.1 (rs401775061 A>C) in TRHDE gene, which were significantly associated with post-weaning gain in sheep. Herein, we performed a replication experiment to investigate single nucleotide polymorphisms (SNPs) within the MEF2B and TRHDE gene exons, the 5'untranslated regions (within 1000bp), the 3' untranslated regions (within 1000bp) and their associations with Ujumqin sheep growth traits in 4-month age and 6-month age, respectively. Finally,3 SNPs were selected to be investigated including 1 SNP in 3'untranslated regions in MEF2B gene (rs417014745 A>G) and 2 SNPs in TRHDE gene (rs426980328 T>C and rs430810656 G>A).The χ2 test showed all the 3 variations were in Hardy-Weinberg equilibrium (P>0.05) status. Association analysis suggested that rs426980328 T>C was significantly associated with body weight and chest girth in 4-month age (P<0.05). rs430810656 G>A exhibited extremely significant association with body weight and chest girth in 4-month age (P<0.01). rs417014745 A>G was extremely significantly associated with body weight and chest girth in 4-month age and chest girth in 6-month age (P<0.01), and it was also significantly associated with body weight in 6-month age (P<0.05). Combined effect analysis indicated significant associations between the combinations of rs426980328-rs417014745, rs430810656-rs417014745 and several growth traits (P<0.05). These results suggested MEF2B and TRHDE genes affected growth traits in Ujumqin sheep and the combination effect of the two genes also played a significant effective role. These SNPs might have potential value as genetic markers for growth traits and it could be used in Ujumqin sheep breeding in future. Further studies are necessary to confirm our findings.
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