SynthesisHuman brain mapping2016
Heterochronicity of white matter development and aging explains regional patient control differences in schizophrenia.
Synthesis in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Ancestral, Pregnancy, and Negative Early-Life Risks Shape Children's Brain (Dis)similarity to Schizophrenia.Biological psychiatry · 2023Pooled it
- ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.Translational psychiatry · 2020Pooled it
- Micro- and Macrostructural White Matter Integrity in Never-Treated and Currently Unmedicated Patients With Schizophrenia and Effects of Short-Term Antipsychotic Treatment.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Trial
- Striatum volume and affective symptomatology are associated with sleep in schizophrenia.Journal of psychiatric research · 2026Article
- Peripheral Microvascular and Cerebral White Matter Dysfunction in Schizophrenia: Implications of a Body-Brain Endothelial Pathophysiology.Schizophrenia bulletin · 2025Article
- Stable White Matter Structure in the First Three Years After Psychosis Onset.Biological psychiatry global open science · 2025Article
- White matter and latency of visual evoked potentials during maturation: A miniature pig model of adolescent development.Journal of neuroscience methods · 2024Article
- Spatiotemporal Patterns of White Matter Maturation after Pre-Adolescence: A Diffusion Kurtosis Imaging Study.Brain sciences · 2024Article
- The Genomic Intersection of Oligodendrocyte Dynamics in Schizophrenia and Aging Unravels Novel Pathological Mechanisms and Therapeutic Potentials.International journal of molecular sciences · 2024Review
- Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along-tract analysis.The European journal of neuroscience · 2022Article
- The additive impact of cardio-metabolic disorders and psychiatric illnesses on accelerated brain aging.Human brain mapping · 2022Article
- Epidermal Growth Factor Pathway in the Age-Related Decline of Oligodendrocyte Regeneration.Frontiers in cellular neuroscience · 2022Review
- Clinical and cortical similarities identified between bipolar disorder I and schizophrenia: A multivariate approach.Frontiers in human neuroscience · 2022Article
- Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients.Frontiers in aging neuroscience · 2022Article
- ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research.Human brain mapping · 2022Article
- White matter brain aging in relationship to schizophrenia and its cognitive deficit.Schizophrenia research · 2021Article
- Neurite Orientation Dispersion and Density Imaging (NODDI) and Duration of Untreated Psychosis in Antipsychotic Medication-Naïve First Episode Psychosis Patients.Neuroimage. Reports · 2021Article
- A White Matter Connection of Schizophrenia and Alzheimer's Disease.Schizophrenia bulletin · 2021Article
- Microstructure of Human Corpus Callosum across the Lifespan: Regional Variations in Axon Caliber, Density, and Myelin Content.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- The Relationship Between Abnormal Resting-State Functional Connectivity of the Left Superior Frontal Gyrus and Cognitive Impairments in Youth-Onset Drug-Naïve Schizophrenia.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
backgroundAltered brain connectivity is implicated in the development and clinical burden of schizophrenia. Relative to matched controls, schizophrenia patients show (1) a global and regional reduction in the integrity of the brain's white matter (WM), assessed using diffusion tensor imaging (DTI) fractional anisotropy (FA), and (2) accelerated age-related decline in FA values. In the largest mega-analysis to date, we tested if differences in the trajectories of WM tract development influenced patient-control differences in FA. We also assessed if specific tracts showed exacerbated decline with aging.
methodsThree cohorts of schizophrenia patients (total n = 177) and controls (total n = 249; age = 18-61 years) were ascertained with three 3T Siemens MRI scanners. Whole-brain and regional FA values were extracted using ENIGMA-DTI protocols. Statistics were evaluated using mega- and meta-analyses to detect effects of diagnosis and age-by-diagnosis interactions.
resultsIn mega-analysis of whole-brain averaged FA, schizophrenia patients had lower FA (P = 10
conclusionWM tracts that mature later in life appeared more sensitive to the pathophysiology of schizophrenia and were more susceptible to faster age-related decline in FA values. Hum Brain Mapp 37:4673-4688, 2016. © 2016 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.