GLP-1 receptor agonists × body weight & composition

TrialEndocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists2016

EFFECTS OF LIRAGLUTIDE 3.0 MG ON WEIGHT AND RISK FACTORS IN HISPANIC VERSUS NON-HIPANIC POPULATIONS: SUBGROUP ANALYSIS FROM SCALE RANDOMIZED TRIALS.

Patrick M O'Neil et al.PubMed ↗Publisher ↗

  • Liraglutide 3.0 mglooks good hereLower weight loss.Weak evidence: one subgroup.

What the trial testedrandomised · 2016

One subgroup

May have lowered weight loss in Hispanic

−5.10percentage points−6.20 to −4.00

liraglutide 3.0 mg vs placebo, in Hispanic

As reported

difference −5.1 %, 95% CI −6.20 to −4.00 · the paper's word: mean weight loss

One subgroup

May have lowered weight loss in non-Hispanic

−5.20percentage points−5.50 to −4.80

liraglutide 3.0 mg vs placebo, in non-Hispanic

As reported

difference −5.2 %, 95% CI −5.50 to −4.80 · the paper's word: mean weight loss

Who was studied, and how

422people in the Effect of Liraglutide on Long-term Weight Maintenance and Additional Weight Loss Induced by a 4 to 12 Week Low Calorie Diet in Obese Subjects; A 56 Week Randomised, Double-blind, Placebo Controlled, Parallel Group, Multicentre Trial With a 12 Week Follow-up Period trial, from 2008
of them with obesity, in this paper

Among Hispanic, the trial randomly assignedassigned by chance

liraglutide 3.0 mg
placebo

May have lowered weight loss−5.10

randomised · one subgroup

Among non-Hispanic, the trial randomly assignedassigned by chance

liraglutide 3.0 mg
placebo

May have lowered weight loss−5.20

randomised · one subgroup

the abstract, start to end

7.0% versus 1.5%, treatment difference -5.1% (95% CI, -6.2 to -4.0); non-Hispanics 7.5% versus 2.3%, -5.2% (95% CI, -5.5 to -4.8).

← favours treatmentfavours comparator →
could be chance
Mean weight lossliraglutide 3.0 mg vs placebo, in Hispanic
−5.1−6.20 to −4.00
Mean weight lossliraglutide 3.0 mg vs placebo, in non-Hispanic
−5.2−5.50 to −4.80
GLP-1 receptor agonistsBody weight & composition

GLP-1 receptor agonists × body weight & compositionhelps?replicated

unlikelylikely
0.900.90 without it
← favours treatmentfavours comparator →
this paperthis paperthis paperthis papermore certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 27482610