Observational studyEuropean journal of clinical pharmacology2016
Statin-induced myopathy in a usual care setting-a prospective observational study of gender differences.
Observational study in European journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Effects of coenzyme Q10 supplementation on myopathy in statin-treated patients: a systematic review and meta-analysis.Journal of nutritional science · 2025Pooled it
- Impact of SLCO1B1 (rs2306283) polymorphism on personalized atorvastatin dosing in a genetically distinct South Asian cohort.BMC pharmacology & toxicology · 2025Article
- Are statin side effects dependent on sex? A narrative review.Przeglad menopauzalny = Menopause review · 2025Review
- Article
- Sex-differences in reporting of statin-associated diabetes mellitus to the US Food and Drug Administration.BMJ open diabetes research & care · 2024Article
- Sex specific analysis of patients with and without reported statin intolerance referred to a specialized outpatient lipid clinic.Biology of sex differences · 2024Article
- Reporting of Drug-Induced Myopathies Associated with the Combination of Statins and Daptomycin: A Disproportionality Analysis Using the US Food and Drug Administration Adverse Event Reporting System.Journal of clinical medicine · 2023Article
- Challenges in Optimizing Lipid Management in Women.Cardiovascular drugs and therapy · 2022Review
- Adequate enrollment of women in cardiovascular drug trials and the need for sex-specific assessment and reporting.American heart journal plus : cardiology research and practice · 2022Article
- Statin Induced Myopathy Among Patients Attending the National Center for Diabetes, endocrinology, & genetics.Annals of medicine and surgery (2012) · 2022Article
- Use of Statins in Kidney Transplant Recipients in Norway.International journal of environmental research and public health · 2022Observational
- A multistate transition model for statin-induced myopathy and statin discontinuation.CPT: pharmacometrics & systems pharmacology · 2021Article
- The Risk of Muscular Events Among New Users of Hydrophilic and Lipophilic Statins: an Observational Cohort Study.Journal of general internal medicine · 2021Observational
- Statin therapy: does sex matter?Menopause (New York, N.Y.) · 2019Review
- Differences in discontinuation of statin treatment in women and men with advanced cancer disease.Biology of sex differences · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe study aims to identify the occurrence and remission of statin-induced myopathy including patient perception and symptom characteristics with a gender perspective.
methodsThe study was designed as a prospective, non-interventional investigation in 192 outpatients receiving statin treatment in usual care with 12 months follow-up. Main outcome measure was myopathy related to statin treatment and classified as probable using WHO criteria for adverse drug reaction (ADR) assessment.
resultsFourteen percent developed myopathy, risk ratio for women 1.52 [95 % CI 1.37; 1.66] as compared to men. The majority graded their pain as "severe." CK values were within normal range. Eighty percent of the women compared to 43 % of the men reported that the muscular symptoms affected their daily life activities to a moderate or severe extent. For those who stopped treatment, mypopathy was the reason for 70 % of the women and 25 % of the men. There was a difference in mean dose between men with and without myopathy, but not in women. Among the patients with myopathy, 76 % reported other ADRs as compared to 21 % of the patients without myopathy (p = 0.002). Twenty-nine percent of the women and 18 % of the men reported other ADRs.
conclusionWomen reported a higher frequency of myopathy and other ADRs as well as a larger impact on daily life activities. In men, but not in women, the risk of myopathy was dose-dependent. Patients with myopathy were more susceptible to other statin-induced ADRs which raises the question about common underlying mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.