Evidence map›Paper›PMID 27488098›Full record

Trial reportMolecular nutrition & food research2016

Urinary excretion of Citrus flavanones and their major catabolites after consumption of fresh oranges and pasteurized orange juice: A randomized cross-over study.

Julian K Aschoff, Ken M Riedl, Jessica L Cooperstone, Josef Högel, Anja Bosy-Westphal, Steven J Schwartz, Reinhold Carle, Ralf M Schweiggert

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Molecular nutrition & food research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  5. Review
  6. Review
  7. Article
  8. Review
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  11. Flavouring Group Evaluation 413 (FGE.413): Naringenin.EFSA journal. European Food Safety Authority · 2024
    Article
  12. Current topics in medicinal chemistry · 2024
    Review
  13. Exploring Human Metabolome after Wine Intake-A Review.Molecules (Basel, Switzerland) · 2023
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Julian K AschoffInstitute of Food Science and Biotechnology, University of Hohenheim, Stuttgart, Germany.
Ken M RiedlDepartment of Food Science & Technology, The Ohio State University, Columbus, OH, USA.
Jessica L CooperstoneDepartment of Food Science & Technology, The Ohio State University, Columbus, OH, USA.
Josef HögelInstitute of Human Genetics, University of Ulm, Ulm, Germany.
Anja Bosy-WestphalInstitute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.
Steven J SchwartzDepartment of Food Science & Technology, The Ohio State University, Columbus, OH, USA.
Reinhold CarleInstitute of Food Science and Biotechnology, University of Hohenheim, Stuttgart, Germany.
Ralf M SchweiggertInstitute of Food Science and Biotechnology, University of Hohenheim, Stuttgart, Germany.
University of Hohenheim · DEThe Ohio State University · USUniversität Ulm · DE

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
NCI NIH HHS P30 CA016058
6 · The paper itself

Abstract

scopeOrange juice contains flavanones including hesperidin and narirutin, albeit at lower concentrations as compared to orange fruit. Therefore, we compared bioavailability and colonic catabolism of flavanones from orange juice to a 2.4-fold higher dose from fresh oranges. METHODS AND

resultsFollowing a randomized two-way cross-over design, 12 healthy subjects consumed a test meal comprising either fresh oranges or pasteurized orange juice, delivering 1774 and 751 μmol of total Citrus flavanones, respectively. Deglucuronidated and desulfated hesperetin, naringenin, and the flavanone catabolites 3-(3'-hydroxy-4'-methoxyphenyl)propionic acid, 3-(3'-hydroxyphenyl)hydracrylic acid, 4-hydroxyhippuric acid, and hippuric acid were quantitated in 24-h urine by UHPLC-MS/MS. Differences in urinary hesperetin excretion were found to be nonsignificant (p = 0.5209) both after consumption of orange fruit (21.6 ± 8.0 μmol) and juice (18.3 ± 7.2 μmol). By analogy, postprandial flavanone catabolite excretions were highly similar between treatments. Excretion of 3-(3'-hydroxy-4'-methoxyphenyl)propionic acid was inversely related to that of hesperetin, illustrating the catabolite/precursor relationship.

conclusionDespite 2.4-fold higher doses, excretion of flavanones from ingested fresh orange fruit did not differ from that following orange juice consumption, possibly due to a saturation of absorption or their entrapment in the fiber-rich matrix of the fruit.

Indexed as

AdultBiological AvailabilityCitrus sinensisCross-Over StudiesDose-Response Relationship, DrugFlavanonesFood AnalysisFruitFruit and Vegetable JuicesHesperidinHippuratesHumansPasteurizationTandem Mass SpectrometryYoung Adult4-hydroxyhippuric acidflavanoneFlavanoneshesperetinHesperidinHippurateshippuric acidnaringeninBioavailabilityFlavonoidsHesperetinMetabolismNaringenin

Identifiers

PMID27488098
PMCPMC7301357
OpenAlexW2487804589

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.