Evidence map›Paper›PMID 27503449›Full record

ReviewInternational review of neurobiology2016

Psychological and Neurobiological Correlates of Food Addiction.

E Kalon, J Y Hong, C Tobin, T Schulte

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in International review of neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05646901 (Involvement of the Gut Microbiota-brain Cross-talk in the Loss of Eating Control), which is not on this map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
28.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05646901 recruitingnot on this mapstarted 2022, after this paper: background citation

Involvement of the Gut Microbiota-brain Cross-talk in the Loss of Eating Control (GMBCrossTalkFood)

TypeobservationalSponsorInstitut d'Investigació Biomèdica de Girona Dr. Josep TruetaRan2022 to 2027Enrolled116ConditionsObesity
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 96 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Socio-demographic, dietary, exercise, and mental health factors associated with food addiction symptoms in university students.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. A review of brain structural and functional changes using MRI technology in patients who received bariatric surgery.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2025
    Review
  17. Article
  18. [Research progress of probiotics regulating intestinal micro-ecological environment in obese patients after bariatric surgery].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

E KalonPalo Alto University, Palo Alto, CA, United States; SRI International, Menlo Park, CA, United States. Electronic address: ekalon@paloaltou.edu.
J Y HongSRI International, Menlo Park, CA, United States.
C TobinPalo Alto University, Palo Alto, CA, United States; National Center for PTSD, VA Palo Alto Health Care System Menlo Park Division, Menlo Park, CA, United States.
T SchultePalo Alto University, Palo Alto, CA, United States; SRI International, Menlo Park, CA, United States.
Menlo School · USSRI International · USVA Palo Alto Health Care System · US

Funding

Neurodegeneration and Brain Function in Aging with HIV and Parkinson's DiseaseR01AA023165 · NIAAA · SRI INTERNATIONAL · PI SCHULTE, TILMAN · 2014 to 2017
$3.0M
NIAAA NIH HHS R01 AA023165
6 · The paper itself

Abstract

Food addiction (FA) is loosely defined as hedonic eating behavior involving the consumption of highly palatable foods (ie, foods high in salt, fat, and sugar) in quantities beyond homeostatic energy requirements. FA shares some common symptomology with other pathological eating disorders, such as binge eating. Current theories suggest that FA shares both behavioral similarities and overlapping neural correlates to other substance addictions. Although preliminary, neuroimaging studies in response to food cues and the consumption of highly palatable food in individuals with FA compared to healthy controls have shown differing activation patterns and connectivity in brain reward circuits including regions such as the striatum, amygdala, orbitofrontal cortex, insula, and nucleus accumbens. Additional effects have been noted in the hypothalamus, a brain area responsible for regulating eating behaviors and peripheral satiety networks. FA is highly impacted by impulsivity and mood. Chronic stress can negatively affect hypothalamic-pituitary-adrenal axis functioning, thus influencing eating behavior and increasing desirability of highly palatable foods. Future work will require clearly defining FA as a distinct diagnosis from other eating disorders.

Indexed as

Feeding and Eating DisordersRewardBehavior, AddictiveBrainHumansMotivationNeurobiologyNeuroimagingAddictive behaviorConnectivityEating addictionfMRIFood addictionFood cuesReward circuitry

Identifiers

PMID27503449
PMCPMC5608024
OpenAlexW2501304836

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.