Evidence map›Paper›PMID 27504014›Full record

Trial reportDiabetes care2016

The Stepwise Approach to Diabetes Prevention: Results From the D-CLIP Randomized Controlled Trial.

Mary Beth Weber, Harish Ranjani, Lisa R Staimez, Ranjit M Anjana, Mohammed K Ali, K M Venkat Narayan, Viswanathan Mohan

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01283308 (The Diabetes Community Lifestyle Improvement Program), which is not on this map. Cited by 100 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 7 pooled it
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01283308 nacompletednot on this map

The Diabetes Community Lifestyle Improvement Program (D-CLIP): A Translation Randomized Trial of a Culturally Specific Lifestyle Intervention for Diabetes Prevention in India

TypeinterventionalSponsorEmory UniversityRan2009 to 2013Enrolled599ConditionsDiabetes Mellitus, Type 2ArmsLifestyle Intervention, Standard of Care
3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 7 syntheses or guidelines pooled it, 186 citations in OpenAlex.

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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Mary Beth WeberEmory Global Diabetes Research Center, Hubert Department of Global Health, Emory University, Atlanta, GA mbweber@emory.edu.
Harish RanjaniMadras Diabetes Research Foundation, Chennai, India.
Lisa R StaimezEmory Global Diabetes Research Center, Hubert Department of Global Health, Emory University, Atlanta, GA.
Ranjit M AnjanaMadras Diabetes Research Foundation, Chennai, India.
Mohammed K AliEmory Global Diabetes Research Center, Hubert Department of Global Health, Emory University, Atlanta, GA.
K M Venkat NarayanEmory Global Diabetes Research Center, Hubert Department of Global Health, Emory University, Atlanta, GA.
Viswanathan MohanMadras Diabetes Research Foundation, Chennai, India.
Emory University · USMadras Diabetes Research Foundation · IN

Funding

ENDOCRINOLOGY, METABOLISM, AND DIABETEST32DK007298 · EMORY UNIVERSITY · 1986 to 2005
$1.1M
NUTRITIONAL SCIENCES AND HEALTHT32DK007734 · EMORY UNIVERSITY · 1997 to 2005
$626k
NIDDK NIH HHS T32 DK007298NIDDK NIH HHS T32 DK007734
6 · The paper itself

Abstract

objectiveThis study tests the effectiveness of expert guidelines for diabetes prevention: lifestyle intervention with addition of metformin, when required, among people with prediabetes. RESEARCH DESIGN AND

methodsThe Diabetes Community Lifestyle Improvement Program (D-CLIP) is a randomized, controlled, translation trial of 578 overweight/obese Asian Indian adults with isolated impaired glucose tolerance (iIGT), isolated impaired fasting glucose (iIFG), or IFG+IGT in Chennai, India. Eligible individuals were identified through community-based recruitment and randomized to standard lifestyle advice (control) or a 6-month, culturally tailored, U.S. Diabetes Prevention Program-based lifestyle curriculum plus stepwise addition of metformin (500 mg, twice daily) for participants at highest risk of conversion to diabetes at ≥4 months of follow-up. The primary outcome, diabetes incidence, was assessed biannually and compared across study arms using an intention-to-treat analysis.

resultsDuring 3 years of follow-up, 34.9% of control and 25.7% of intervention participants developed diabetes (P = 0.014); the relative risk reduction (RRR) was 32% (95% CI 7-50), and the number needed to treat to prevent one case of diabetes was 9.8. The RRR varied by prediabetes type (IFG+IGT, 36%; iIGT, 31%; iIFG, 12%; P = 0.77) and was stronger in participants 50 years or older, male, or obese. Most participants (72.0%) required metformin in addition to lifestyle, although there was variability by prediabetes type (iIFG, 76.5%; IFG+IGT, 83.0%; iIGT, 51.3%).

conclusionsStepwise diabetes prevention in people with prediabetes can effectively reduce diabetes incidence by a third in community settings; however, people with iIFG may require different interventions.

Indexed as

Life StyleAdultBlood GlucoseBody Mass IndexDiabetes MellitusDietFemaleFollow-Up StudiesGlucose IntoleranceGlycated HemoglobinHumansIncidenceIndiaMaleMetforminMiddle AgedBlood GlucoseGlycated HemoglobinMetformin

Identifiers

PMID27504014
PMCPMC5033082
OpenAlexW2507211385

What Socratic holds

Texttitle and abstract
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.