ArticleDevelopment (Cambridge, England)2016
A novel small molecule that disrupts a key event during the oocyte-to-embryo transition in C. elegans.
Article in Development (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Proteostasis Rebalancing by LET-607 Deficiency Promotes Longevity.Aging cell · 2026Article
- Drug screens using the nematode Caenorhabditis elegans.Genetics · 2025Review
- Microfluidic approach to correlateLab on a chip · 2024Article
- C22 disrupts embryogenesis and extendsFrontiers in physiology · 2023Article
- Meta-Analysis ofFrontiers in microbiology · 2022Article
- Phosphatidylcholine mediates the crosstalk between LET-607 and DAF-16 stress response pathways.PLoS genetics · 2021Article
- Secrets of secretion-How studies of the Drosophila salivary gland have informed our understanding of the cellular networks underlying secretory organ form and function.Current topics in developmental biology · 2021Article
- Combining Auxin-Induced Degradation and RNAi Screening Identifies Novel Genes Involved in Lipid Bilayer Stress Sensing inG3 (Bethesda, Md.) · 2020Article
- Quantitative Approaches for Scoring in vivo Neuronal Aggregate and Organelle Extrusion in Large Exopher Vesicles in C. elegans.Journal of visualized experiments : JoVE · 2020Article
- An automated platform to monitor long-term behavior and healthspan in Caenorhabditis elegans under precise environmental control.Communications biology · 2020Article
- Article
- A simple culture system for long-term imaging of individual C. elegans.Lab on a chip · 2017Article
- A species-specific nematocide that results in terminal embryogenesis.The Journal of experimental biology · 2017Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
The complex cellular events that occur in response to fertilization are essential for mediating the oocyte-to-embryo transition. Here, we describe a comprehensive small-molecule screen focused on identifying compounds that affect early embryonic events in Caenorhabditis elegans We identify a single novel compound that disrupts early embryogenesis with remarkable stage and species specificity. The compound, named C22, primarily impairs eggshell integrity, leading to osmotic sensitivity and embryonic lethality. The C22-induced phenotype is dependent upon the upregulation of the LET-607/CREBH transcription factor and its candidate target genes, which primarily encode factors involved in diverse aspects of protein trafficking. Together, our data suggest that in the presence of C22, one or more key components of the eggshell are inappropriately processed, leading to permeable, inviable embryos. The remarkable specificity and reversibility of this compound will facilitate further investigation into the role and regulation of protein trafficking in the early embryo, as well as serve as a tool for manipulating the life cycle for other studies such as those involving aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.