ArticleBMC genomics2016
High concentrations of atmospheric ammonia induce alterations of gene expression in the breast muscle of broilers (Gallus gallus) based on RNA-Seq.
Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Doping of PDMS-NQS Sensors to Modify Their Response and Sustainability: Ammonia Quantitation in Farm Atmospheres as a Case Study.Polymers · 2025Article
- Pathological and molecular investigation of infectious bronchitis in broilers: analyzing the impact of biosecurity lapses.Frontiers in veterinary science · 2025Article
- RNA-Seq Reveals Pathways Responsible for Meat Quality Characteristic Differences between Two Yunnan Indigenous Chicken Breeds and Commercial Broilers.Foods (Basel, Switzerland) · 2024Article
- Effects of Atmospheric Ammonia on Skeletal Muscle Growth in Broilers.Animals : an open access journal from MDPI · 2023Article
- Effects of Different Ammonia Concentrations on Pulmonary Microbial Flora, Lung Tissue Mucosal Morphology, Inflammatory Cytokines, and Neurotransmitters of Broilers.Animals : an open access journal from MDPI · 2022Article
- Jejunal Transcriptomic Profiling for Differences in Feed Conversion Ratio in Slow-Growing Chickens.Animals : an open access journal from MDPI · 2021Article
- Exploring the Multimodal Role ofAnimals : an open access journal from MDPI · 2021Article
- Effects of Ammonia on Gut Microbiota and Growth Performance of Broiler Chickens.Animals : an open access journal from MDPI · 2021Article
- Broilers' head behavior as an early warning index of production and lung health under ammonia exposure.Poultry science · 2021Article
- PTEN/AKT/mTOR pathway involvement in autophagy, mediated by miR-99a-3p and energy metabolism in ammonia-exposed chicken bursal lymphocytes.Poultry science · 2021Article
- Exposure to High Aerial Ammonia Causes Hindgut Dysbiotic Microbiota and Alterations of Microbiota-Derived Metabolites in Growing Pigs.Frontiers in nutrition · 2021Article
- Ammonia Exposure Induced Cilia Dysfunction of Nasal Mucosa in the Piglets.BioMed research international · 2020Article
- Atmospheric Ammonia Affects Myofiber Development and Lipid Metabolism in Growing Pig Muscle.Animals : an open access journal from MDPI · 2019Article
- Effects of stocking density on growth performance, growth regulatory factors, and endocrine hormones in broilers under appropriate environments.Poultry science · 2019Article
- Hepatic transcriptome profile of sheep (Ovis aries) in response to overgrazing: novel genes and pathways revealed.BMC genetics · 2019Article
- Ammonia exposure induced abnormal expression of cytokines and heat shock proteins via glucose metabolism disorders in chicken neutrophils.Environmental science and pollution research international · 2019Article
- RNA-Seq transcriptome analysis of breast muscle in Pekin ducks supplemented with the dietary probiotic Clostridium butyricum.BMC genomics · 2018Article
- Ammonia production in poultry houses can affect health of humans, birds, and the environment-techniques for its reduction during poultry production.Environmental science and pollution research international · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh concentrations of atmospheric ammonia are one of the key environmental stressors affecting broiler production performance, which causes remarkable economic losses as well as potential welfare problems of the broiler industry. Previous reports demonstrated that high levels of ammonia altered body fat distribution and meat quality of broilers. However, the molecular mechanisms and metabolic pathways in breast muscle altered by high concentrations of ambient ammonia exposure on broilers are still unknown.
resultsThis study utilized RNA-Seq to compare the transcriptomes of breast muscles to identify differentially enriched genes in broilers exposed to high and low concentrations of atmospheric ammonia. A total of 267 promising candidate genes were identified by differential expression analysis, among which 67 genes were up-regulated and 189 genes were down-regulated. Bioinformatics analysis suggested that the up and down-regulation of these genes were involved in the following two categories of cellular pathways and metabolisms: Steroid biosynthesis (gga00100) and peroxisome proliferator-activated receptor (PPAR) signaling pathway (gga03320), which both participated in the lipid metabolism processes.
conclusionsThis study suggests that longtime exposure to high concentrations of aerial ammonia can change fat content in breast muscle, meat quality and palatability via altering expression level of genes participating in important lipid metabolism pathways. These findings have provided novel insights into our understanding of molecular mechanisms of breast muscles exposed to ammonia in broilers. This study provides new information that could be used for genetic breeding and nutritional intervention in production practice of broilers industry in the future.
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