ReviewDisease markers2016
Inflammatory Biomarkers Profile as Microenvironmental Expression in Keratoconus.
Review in Disease markers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 5 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Toll-like receptors in corneal ectasia: linking innate immunity to keratoconus.Molecular biology reports · 2026Pooled it
- Corneal Allogeneic Intrastromal Ring Segments for Treating Keratoconus-Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2026Pooled it
- The candidate proteins associated with keratoconus: A meta-analysis and bioinformatic analysis.PloS one · 2024Pooled it
- Systematically Displaying the Pathogenesis of KeratoconusFrontiers in medicine · 2021Pooled it
- Pooled it
- Influence of interleukin 17 A and 17 F polymorphisms in keratoconus.Molecular biology reports · 2021Trial
- Imbalance of Pro-Oxidant and Anti-Oxidant Biomarkers in Patients with Keratoconus.Antioxidants (Basel, Switzerland) · 2026Article
- Exploring biomarkers for keratoconus: current insights and future directions.Molecular biology reports · 2025Review
- The microenvironment of ocular surface in keratoconus: a systematic review.Eye and vision (London, England) · 2025Review
- Comparison of the 1-year efficacy of epithelium-off and transepithelial accelerated corneal collagen crosslinking in adolescent keratoconus.Eye (London, England) · 2025Observational
- Omics in Keratoconus: From Molecular to Clinical Practice.Journal of clinical medicine · 2025Review
- Causal Relationship Between Common Allergic Diseases and Keratoconus: A Two-Sample Mendelian Randomization Study.Translational vision science & technology · 2025Article
- Correlations between tear lymphocytotoxin-a (LT-α) level and disease severity in adult keratoconus.Frontiers in medicine · 2025Article
- Blast injury: Impact to the cornea.Experimental eye research · 2024Review
- Identification of hub genes and molecular pathways in keratoconus by integrating bioinformatics and literature mining at the RNA level.International ophthalmology · 2024Article
- Expression of Tissue Inhibitors of Metalloproteinases (TIMP-1, TIMP-2, TIMP-3, TIMP-4) in Blood Serum of Patients with Keratoconus.Journal of clinical medicine · 2024Article
- Systemic and Ocular Associations of Keratoconus.Expert review of ophthalmology · 2024Article
- Level of Secretion and the Role of the Nerve Growth Factor in Patients with Keratoconus before and after Collagen Fibre Cross-Linking Surgery.International journal of molecular sciences · 2023Article
- Serum inflammatory biomarkers are associated with increased choroidal thickness in keratoconus.Scientific reports · 2023Article
- Bowman Layer Transplantation for Treating Keratoconus-Preliminary Findings.Journal of clinical medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keratoconus is a degenerative disorder with progressive stromal thinning and transformation of the normal corneal architecture towards ectasia that results in decreased vision due to irregular astigmatism and irreversible tissue scarring. The pathogenesis of keratoconus still remains unclear. Hypotheses that this condition has an inflammatory etiopathogenetic component apart from the genetic and environmental factors are beginning to escalate in the research domain. This paper covers the most relevant and recent published papers regarding the biomarkers of inflammation, their signaling pathway, and the potentially new therapeutic options in keratoconus.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.