Evidence mapPaperPMID 27568804Full record

Trial reportSleep2016

Effect of Adenotonsillectomy on Parent-Reported Sleepiness in Children with Obstructive Sleep Apnea.

Shalini Paruthi, Paula Buchanan, Jia Weng, Ronald D Chervin, Ronald B Mitchell, Dawn Dore-Stites, Anjali Sadhwani, Eliot S Katz, John Bent, Carol L Rosen and 2 more

Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00560859 (A Randomized Controlled Study of Adenotonsillectomy for Children With Obstructive Sleep Apnea Syndrome), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00560859 nacompletednot on this map

A Randomized Controlled Study of Adenotonsillectomy for Children With Obstructive Sleep Apnea Syndrome

TypeinterventionalSponsorUniversity of PennsylvaniaRan2007 to 2012Enrolled453ConditionsObstructive Sleep Apnea, SnoringArmsAdenotonsillectomy (AT) - removal of adenoids and tonsils, Watchful Waiting
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Recommended protocols for the Multiple Sleep Latency Test and Maintenance of Wakefulness Test in children: guidance from the American Academy of Sleep Medicine.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Sleep disorders in children with celiac disease: a prospective study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 1 country.

Shalini ParuthiDepartment of Pediatrics, Saint Louis University, St. Louis, MO.
Paula BuchananSaint Louis University Center for Outcomes Research, St. Louis, MO.
Jia WengDivision of Sleep Medicine, Brigham and Women's Hospital, Boston, MA.
Ronald D ChervinDepartment of Neurology and Sleep Disorders Center, University of Michigan, Ann Arbor, MI.
Ronald B MitchellDepartment of Otolaryngology, University of Texas Southwestern, Dallas, Texas.
Dawn Dore-StitesDepartment of Pediatrics, University of Michigan Health System, Ann Arbor, MI.
Anjali SadhwaniBoston Children's Hospital, Boston, MA.
Eliot S KatzDivision of Respiratory Diseases, Boston Children's Hospital, Boston, MA.
John BentDepartments of Otolaryngology-Head and Neck Surgery and Pediatrics, Albert Einstein College of Medicine, Bronx, NY.
Carol L RosenDepartment of Pediatrics, Rainbow Babies & Children's Hospital, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH.
Susan RedlineDepartments of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Carole L MarcusDepartment of Pediatrics, Sleep Center, Children's Hospital of Philadelphia; University of Pennsylvania, Philadelphia, PA.
Brigham and Women's Hospital · USSaint Louis University · USAlbert Einstein College of Medicine · USBoston Children's Hospital · USBoston Children's Museum · USChildren's Hospital of Philadelphia · USMichigan Medicine · USRainbow Babies & Children's Hospital · USThe University of Texas Southwestern Medical Center · USUniversity of Michigan–Ann Arbor · US

Funding

NCRR NIH HHS UL1 RR024134NHLBI NIH HHS U01 HL083075
6 · The paper itself

Abstract

STUDY

objectivesTo describe parental reports of sleepiness and sleep duration in children with polysomnography (PSG)-confirmed obstructive sleep apnea (OSA) randomized to early adenotonsillectomy (eAT) or watchful waiting with supportive care (WWSC) in the ChildHood Adenotonsillectomy Trial (CHAT). We hypothesized children with OSA would have a larger improvement in sleepiness 6 mo following eAT compared to WWSC.

methodsParents of children aged 5.0-9.9 y completed the Epworth Sleepiness Scale modified for children (mESS) and the Pediatric Sleep Questionnaire-Sleepiness Subscale (PSQ-SS). PSG was performed at baseline and at 7-mo endpoint. Children underwent early adenotonsillectomy or WWSC.

resultsThe mESS and PSQ-SS classified 24% and 53% of the sample as excessively sleepy, respectively. At baseline, mean mESS score was 7.4 ± 5.0 (SD) and mean PSQ-SS score was 0.44 ± 0.30. Sleepiness scores were higher in African American children; children with shorter sleep duration; older children; and overweight children. At endpoint, mean mESS score decreased by 2.0 ± 4.2 in the eAT group versus 0.3 ± 4.0 in the WWSC group (P < 0.0001); mean PSQ-SS score decreased 0.29 ± 0.40 in eAT versus 0.08 ± 0.40 in the WWSC group (P < 0.0001). Despite higher baseline sleepiness, African American children experienced similar improvement with adenotonsillectomy than other children. Improvement in sleepiness was weakly associated with improved apnea-hypopnea index or oxygen desaturation indices, but not with change in other polysomnographic measures.

conclusionsSleepiness assessed by parent report was prevalent; improved more after eAT than after WWSC; and was not strongly predicted by sleep disturbances identified by PSG. CLINICAL

trial registrationChildhood Adenotonsillectomy Study for Children with OSA (CHAT). ClinicalTrials.gov Identifier #NCT00560859.

Indexed as

AdenoidectomySleep StagesTonsillectomyChildChild, PreschoolDisorders of Excessive SomnolenceFemaleFollow-Up StudiesHumansMaleParentsSleep Apnea, ObstructiveTreatment OutcomeWatchful Waitingadenotonsillectomyapnea-hypopnea indexEpworth Sleepiness ScaleOSAOSASpediatricPediatric Sleep Questionnairepolysomnogramsleepiness

Identifiers

PMID27568804
PMCPMC5070754
OpenAlexW2509817404

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.