SynthesisHuman molecular genetics2016
Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Human molecular genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
5.1field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- A large genome-wide association study of QT interval length utilizing electronic health records.Genetics · 2022Pooled it
- Identification of genetic effects underlying type 2 diabetes in South Asian and European populations.Communications biology · 2022Pooled it
- GWAS of the electrocardiographic QT interval in Hispanics/Latinos generalizes previously identified loci and identifies population-specific signals.Scientific reports · 2017Pooled it
- NovelBiomedicines · 2026Article
- The cardiac conduction system: development, function and therapeutic targets.Nature reviews. Cardiology · 2026Review
- Multiparity induces persistent myocardial structural, functional and transcriptomic remodelling in mice.Scientific reports · 2025Article
- Deficiency in Prader-Willi syndrome geneiScience · 2024Article
- Discovery ofBiology · 2023Article
- Importance of Diversity in Precision Medicine: Generalizability of Genetic Associations Across Ancestry Groups Toward Better Identification of Disease Susceptibility Variants.Annual review of biomedical data science · 2023Review
- Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- Genetic architecture of heart failure with preserved versus reduced ejection fraction.Nature communications · 2022Article
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- HAND transcription factors cooperatively specify the aorta and pulmonary trunk.Developmental biology · 2021Article
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- The Role ofFrontiers in cell and developmental biology · 2021Review
- Genome-wide association studies of cardiac electrical phenotypes.Cardiovascular research · 2020Review
- Sequence variants with large effects on cardiac electrophysiology and disease.Nature communications · 2019Article
- Allele-specific NKX2-5 binding underlies multiple genetic associations with human electrocardiographic traits.Nature genetics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
62 authors at 20 institutions in 4 countries.
Daniel S EvansCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA devans@psg.ucsf.edu. nsotoo@u.washington.edu.
Christy L AveryDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Guo LiCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
John BarnardDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Erin N SmithDepartment of Pediatrics and Rady Children's Hospital, University of California at San Diego, School of Medicine, La Jolla, CA, USA.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Anne M ButlerDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Sarah G BuxbaumCenter of Excellence in Minority Health and Health Disparities, Jackson State University, Jackson, MS, USA.
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gerald S BerensonDepartment of Medicine and Cardiology, Tulane University, New Orleans, LA, USA.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Steven BuyskeDepartment of Statistics and Biostatistics and Department of Genetics, Rutgers University, Piscataway, NJ, USA.
Cara L CartyDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Wei ChenDepartment of Epidemiology, Tulane University, New Orleans, LA, USA.
Mina K ChungDepartment of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA.
Steven R CummingsCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
Rajat DeoDivision of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Charles B EatonDepartments of Family Medicine and Epidemiology, Alpert Medical School, Brown University, Providence, RI, USA.
Ervin R FoxDepartment of Medicine, Division of Cardiovascular Disease, University of Mississippi Medical Center, Jackson, MS, USA.
Susan R HeckbertCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Gerardo HeissDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Lucia A HindorffNational Institutes of Health, National Human Genome Research Institute, Office of Population Genomics, Bethesda, MD, USA.
Wen-Chi HsuehPhoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA.
Aaron IsaacsGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Yalda JamshidiCardiogenetics Lab, Institute of Cardiovascular and Cell Sciences, St George's University of London, UK.
Kathleen F KerrDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Felix LiuDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Yongmei LiuDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, NC, USA.
Kurt K LohmanDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, NC, USA.
Jared W MagnaniDepartment of Medicine, Division of Cardiology, University of Pittsburgh Medical Center Heart and Vascular Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Joseph F MaherDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Reena MehraProgram for Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.
Yan A MengJackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA.
Solomon K MusaniCardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston,MA, USA.
Christopher Newton-ChehJackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA.
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Susan RedlineInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Departments of Medicine and Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.
Jerome I RotterUniversity Heart Center Hamburg and German Center for Cardiovascular Research, Hamburg, Germany.
Renate B SchnabelJ. Craig Venter Institute, San Diego, CA, USA.
Nicholas J SchorkCenter for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
Ralph V ShohetDepartment of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH, USA.
Andrew B SingletonLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Jonathan D SmithEpidemiological Cardiology Research Center (EPICARE), Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Elsayed Z SolimanDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Sathanur R SrinivasanDepartment of Epidemiology, Tulane University, New Orleans, LA, USA.
Herman A TaylorDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
David R Van WagonerDepartment of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
James G WilsonLaboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Taylor YoungJackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA.
Zhu-Ming ZhangDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Alan B ZondermanDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Michele K EvansDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Sarah S MurrayDepartment of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Gregory J TranahCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
Eric A WhitselDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Alex P ReinerCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
CHARGE QRS Consortium
Nona SotoodehniaDepartment of Epidemiology, University of Washington, Seattle, WA, USA devans@psg.ucsf.edu. nsotoo@u.washington.edu.
University of North Carolina at Chapel Hill · USNational Institutes of Health · USUniversity of Mississippi Medical Center · USUniversity of Washington · USCalifornia Pacific Medical Center · USCleveland Clinic Lerner College of Medicine · USTulane University · USWake Forest University · USFred Hutch Cancer Center · USJackson Memorial Hospital · USNational Institute on Aging · USUniversity of California San Diego · USBrigham and Women's Hospital · USBroad Institute · USBrown University · USCleveland Clinic · USEmory University · USErasmus MC · NLGerman Centre for Cardiovascular Research · DEGroup Health Cooperative · US
Funding
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MZosuquidar trihydrochloride for acute myeloid leukemia &refractory anemiaM01RR000080 · NCRR · UNIVERSITY HOSPITALS OF CLEVELAND · PI DEARBORN, DORR GELLATLY · 1985 to 2007
$22.2MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MEpidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8MEVOLUTION OF CARDIOVASCULAR RISK WITH NORMAL AGINGR01AG016592 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, WEI · 2000 to 2015
$11.7MCharacterization of Normal Genomic VariabilityZIAAG000932 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW · 2009 to 2024
$11.3MMulti-Ethnic Study of Atherosclerosis (MESA) StudyR01HL071205 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI ROTTER, JEROME I · 2003 to 2007
$10.4MResearch Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6MExceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MIntramural NIH HHS Z01 AG000513NCATS NIH HHS UL1 TR000124NCI NIH HHS T32 CA009330NCRR NIH HHS M01 RR000080NCRR NIH HHS UL1 RR025005NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG007376NHGRI NIH HHS U01 HG007397NHGRI NIH HHS U01 HG007416NHGRI NIH HHS U01 HG007417NHGRI NIH HHS U01 HG007419NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS K99 HL098458NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC065226NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R00 HL098458NHLBI NIH HHS R01 HL046380NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL071205NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL088456NHLBI NIH HHS R01 HL090620NHLBI NIH HHS R01 HL091244NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL111089NHLBI NIH HHS R01 HL111314NHLBI NIH HHS R01 HL116747NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NIA NIH HHS HHSN271201100004CNIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS R01 AG016592NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG032098NIA NIH HHS R56 AG023629NIA NIH HHS U24 AG051129NIDDK NIH HHS P30 DK063491NIEHS NIH HHS R01 ES017794NIEHS NIH HHS R01 ES021724NIMHD NIH HHS P20 MD006899NINDS NIH HHS U54 NS056883WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
Abstract
The electrocardiographic QRS duration, a measure of ventricular depolarization and conduction, is associated with cardiovascular mortality. While single nucleotide polymorphisms (SNPs) associated with QRS duration have been identified at 22 loci in populations of European descent, the genetic architecture of QRS duration in non-European populations is largely unknown. We therefore performed a genome-wide association study (GWAS) meta-analysis of QRS duration in 13,031 African Americans from ten cohorts and a transethnic GWAS meta-analysis with additional results from populations of European descent. In the African American GWAS, a single genome-wide significant SNP association was identified (rs3922844, P = 4 × 10
Indexed as
Genome-Wide Association StudyAllelesBlack or African AmericanCardiovascular DiseasesElectrocardiographyFemaleGenotypeHeart VentriclesHumansMaleMyocardiumNAV1.5 Voltage-Gated Sodium ChannelPolymorphism, Single NucleotideWhite PeopleNAV1.5 Voltage-Gated Sodium ChannelSCN5A protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.