ArticleAlimentary pharmacology & therapeutics2016
Dietary carbohydrate intake, insulin resistance and gastro-oesophageal reflux disease: a pilot study in European- and African-American obese women.
Article in Alimentary pharmacology & therapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Higher Carbohydrate Amount and Lower Glycemic Index Increase Hunger, Diet Satisfaction, and Heartburn in Overweight and Obese Adults in the OmniCarb Randomized Clinical Trial.The Journal of nutrition · 2021Trial
- Sex-specific association of visceral and abdominal subcutaneous adipose tissue with gastroesophageal reflux disease: a large-scale perspective cohort study.BMC gastroenterology · 2025Article
- Myths and Facts Regarding Low-Carbohydrate Diets.Nutrients · 2025Review
- Unveiling the intricacies: Insight into gastroesophageal reflux disease.World journal of gastroenterology · 2025Review
- Update Motility Disorders: Gastro-Oesophageal Reflux Disease - Diagnostic and Conservative Approach.Visceral medicine · 2024Review
- Metabolic dysfunction-associated steatotic liver disease and gastroesophageal reflux disease: a mendelian randomization study in European and East Asian populations.Frontiers in genetics · 2024Article
- Current complementary and alternative therapy forgastroesophageal reflux disease.Gastroenterology report · 2023Review
- Role of Nutrition in Gastroesophageal Reflux, Irritable Bowel Syndrome, Celiac Disease, and Inflammatory Bowel Disease.Gastro hep advances · 2023Review
- Objective ambulatory pH monitoring and subjective symptom assessment of gastroesophageal reflux disease show type of carbohydrate and type of fat matter.Therapeutic advances in gastroenterology · 2022Article
- The Association between Free Sugars Consumption and Laryngopharyngeal Reflux: A Cross-Sectional Study among Chinese Adolescents.Nutrients · 2021Article
- Metabolically Healthy Obesity and the Risk of Erosive Esophagitis: A Cohort Study.Clinical and translational gastroenterology · 2019Article
- The role of diet in the development and management of gastroesophageal reflux disease: why we feel the burn.Journal of thoracic disease · 2019Review
- Popular Remedies for Esophageal Symptoms: a Critical Appraisal.Current gastroenterology reports · 2019Review
- Obesity increases the risk of erosive esophagitis but metabolic unhealthiness alone does not: a large-scale cross-sectional study.BMC gastroenterology · 2018Observational
- Can We Use Diet to Effectively Treat Esophageal Disease? A Review of the Current Literature.Current gastroenterology reports · 2017Review
- Differences in the Insulin Resistance Levels Measured by HOMA-IR between Patients with Erosive and Non-Erosive Gastroesophageal Reflux Disease.Journal of the ASEAN Federation of Endocrine Societies · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlthough obesity rates are higher in African-American than European-American women, gastro-oesophageal reflux disease (GERD) and its comorbidities are more prevalent in European-American women. A common denominator for increased adiposity, and consequent insulin resistance, is excess dietary macronutrient intake - which may promote greater prevalence and severity of GERD in women.
aimTo investigate whether GERD is more robustly associated with dietary carbohydrate intake, particularly dietary simple carbohydrate intake, and insulin resistance in European-American women.
methodsAbout 144 obese women were assessed at baseline and 16 weeks after consuming a high-fat/low-carbohydrate diet. GERD diagnosis and medication usage was confirmed in medical records with symptoms and medications assessed weekly.
resultsAbout 33.3% (N = 33) of European-American and 20.0% (N = 9) of African-American women had GERD at baseline. Total carbohydrate (r = 0.34, P < 0.001), sugars (r = 0.30, P = 0.005), glycaemic load (r = 0.34, P = 0.001) and HOMA
conclusionsGERD symptoms and medication usage was more prevalent in European-American women, for whom the relationships between dietary carbohydrate intake, insulin resistance and GERD were most significant. Nevertheless, high-fat/low-carbohydrate diet benefited all women with regard to reducing GERD symptoms and frequency of medication use.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.