Evidence map›Paper›PMID 27588495›Full record

ArticleOncotarget2016

Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice.

Zhengxue Liu, Tanima Kundu-Roy, Isao Matsuura, Guannan Wang, Yong Lin, You-Rong Lou, Nicola J Barnard, Xiao-Fan Wang, Mou-Tuan Huang, Nanjoo Suh and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 12 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Zhengxue LiuCenter for Advanced Biotechnology and Medicine, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Tanima Kundu-RoyCenter for Advanced Biotechnology and Medicine, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Isao MatsuuraCenter for Advanced Biotechnology and Medicine, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Guannan WangCenter for Advanced Biotechnology and Medicine, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Yong LinDepartment of Biostatistics, School of Public Health, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
You-Rong LouSusan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Nicola J BarnardDepartment of Pathology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.
Xiao-Fan WangDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA.
Mou-Tuan HuangSusan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Nanjoo SuhSusan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Fang LiuCenter for Advanced Biotechnology and Medicine, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Rutgers, The State University of New Jersey · USRutgers Cancer Institute of New JerseyChongqing Three Gorges University · CNDuke Medical Center · US

Funding

Role of Smad proteins in cell growth regulationR01CA093771 · NCI · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI LIU, FANG · 2002 to 2006
$1.3M
NCI NIH HHS R01 CA093771
6 · The paper itself

Abstract

Previous studies based on cell culture and xenograft animal models suggest that Smad3 has tumor suppressor function for breast cancer during early stages of tumorigenesis. In this report, we show that DMBA (7,12-dimethylbenz[a]anthracene), a chemical carcinogen, induces mammary tumor formation at a significantly higher frequency in the Smad3 heterozygous mice than in the Smad3 wild type mice. This is the first genetic evidence showing that Smad3 inhibits mammary tumor formation in a mouse model. Our findings support the notion that Smad3 has important tumor suppressor function for breast cancer.

Indexed as

Carcinogenesis9,10-Dimethyl-1,2-benzanthraceneAdenocarcinomaAnimalsCarcinogensFemaleHeterozygoteMaleMammary Neoplasms, ExperimentalMiceMice, 129 StrainMice, Inbred C57BLMice, KnockoutSmad3 ProteinTumor Suppressor Proteins9,10-Dimethyl-1,2-benzanthraceneCarcinogensSmad3 ProteinSmad3 protein, mouseTumor Suppressor Proteinsbreast cancercarcinogenesisDMBASmad3TGF-ß

Identifiers

PMID27588495
PMCPMC5323122
OpenAlexW2515660327

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.