Evidence map›Paper›PMID 27621249›Full record

Trial reportMaturitas2016

Stellate ganglion blockade and verbal memory in midlife women: Evidence from a randomized trial.

Pauline M Maki, Leah H Rubin, Antonia Savarese, Lauren Drogos, Lee P Shulman, Suzanne Banuvar, David R Walega

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Maturitas, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
  2. Observational
  3. Menopausal vasomotor symptoms and plasma Alzheimer disease biomarkers.American journal of obstetrics and gynecology · 2024
    Article
  4. Vasomotor symptoms and cardiovascular health: findings from the SWAN and the MsHeart/MsBrain studies.Climacteric : the journal of the International Menopause Society · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Understanding the impact of sex and gender in Alzheimer's disease: A call to action.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Pauline M MakiDepartment of Psychiatry, University of Illinois at Chicago, Neuropsychiatric Institute, MC 913, 912 S. Wood St., Chicago, IL, 60612, USA; Department of Psychology, University of Illinois at Chicago, 1007 W. Harrison St., Chicago, IL, 60607, USA. Electronic address: pmaki@psych.uic.edu.
Leah H RubinDepartment of Psychiatry, University of Illinois at Chicago, Neuropsychiatric Institute, MC 913, 912 S. Wood St., Chicago, IL, 60612, USA. Electronic address: lrubin@psych.uic.edu.
Antonia SavareseGraduate Program in Neuroscience, University of Illinois at Chicago, Psychiatric Institute MC 912, 1601W. Taylor St., Chicago, IL, 60612, USA. Electronic address: asavarese@psych.uic.edu.
Lauren DrogosDepartment of Psychology, University of Illinois at Chicago, 1007 W. Harrison St., Chicago, IL, 60607, USA. Electronic address: ldrogos@gmail.com.
Lee P ShulmanDepartment of Obstetrics and Gynecology, Prentice Women's Hospital, 250 E. Superior Street, Room 05-2174, Chicago, IL, 60611 USA. Electronic address: Lee.Shulman@nm.org.
Suzanne BanuvarDepartment of Anesthesiology, Northwestern University Feinberg School of Medicine, 251 East Huron Street, Suite 5-704 Chicago, IL, 60611 USA. Electronic address: s-banuvar@northwestern.edu.
David R WalegaDepartment of Anesthesiology, Northwestern University Feinberg School of Medicine, 251 East Huron Street, Suite 5-704 Chicago, IL, 60611 USA. Electronic address: d-walega@northwestern.edu.
University of Illinois Chicago · USNorthwestern University · USWomen's Hospital · US

Funding

NICHD NIH HHS K12 HD055892
6 · The paper itself

Abstract

objectivesIn a pilot randomized clinical trial of active stellate ganglion blockade (SGB) versus sham control, SGB significantly reduced the frequency of reported moderate to severe vasomotor symptoms (VMS) and the frequency of physiologic VMS measured using ambulatory skin conductance monitors. Here we examine secondary effects of SGB on verbal learning and memory. STUDY

designIn a randomized, sham-controlled study, 36 women met eligibility criteria for cognitive assessments, of whom 17 were randomized to receive fluoroscopy-guided SGB and 19 to sham control.

main outcome measuresAt baseline and three months post-treatment, women completed tests of verbal learning and memory (primary outcome) and other cognitive measures and also wore an ambulatory monitor for 24h to measure physiologic VMS and VMS reported in real time.

resultsVerbal learning improved following active SGB (p<0.05) but not sham treatment; however, the interaction between group and time was not significant (p values 0.13-0.20). Two secondary cognitive measures improved only in the sham group. Improvements in physiologic VMS correlated significantly with improvements in verbal learning (r=0.51, p<0.05).

conclusionsSGB might confer benefits to memory in relation to the magnitude of improvement in physiologic VMS. Broadly these findings suggest a possible link between physiologic VMS and memory problems in midlife women.

Indexed as

Autonomic Nerve BlockMemoryStellate GanglionVerbal LearningFemaleHot FlashesHumansMiddle AgedSkin Physiological PhenomenaHot flashMemoryMenopauseStellate ganglion blockadeVasomotor symptoms

Identifiers

PMID27621249
PMCPMC5147742
OpenAlexW2484256475

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.