Evidence map›Paper›PMID 27622388›Full record

ArticleAging2016

PPARβ/δ selectively regulates phenotypic features of age-related macular degeneration.

Mayur Choudhary, Jin-Dong Ding, Xiaoping Qi, Michael E Boulton, Pei-Li Yao, Jeffrey M Peters, Goldis Malek

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. Ablation of Fatty Acid Transport Protein-4 Enhances Cone Survival, M-cone Vision, and Synthesis of Cone-Tropic 9-The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  4. Review
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  6. Review
  7. Article
  8. Review
  9. Article
  10. Gene Delivery of a Caspase Activation and Recruitment Domain Improves Retinal Pigment Epithelial Function and Modulates Inflammation in a Mouse Model with Features of Dry Age-Related Macular Degeneration.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2022
    Article
  11. Osteopontin accumulates in basal deposits of human eyes with age-related macular degeneration and may serve as a biomarker of aging.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. PPARs and Angiogenesis-Implications in Pathology.International journal of molecular sciences · 2020
    Review
  20. Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling UsingInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Mayur ChoudharyDepartment of Ophthalmology, Duke University School of Medicine, Durham, NC 27703, USA.
Jin-Dong DingDepartment of Ophthalmology, Duke University School of Medicine, Durham, NC 27703, USA.
Xiaoping QiDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Michael E BoultonDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Pei-Li YaoDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Jeffrey M PetersDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Goldis MalekDepartment of Ophthalmology, Duke University School of Medicine, Durham, NC 27703, USA.
Duke University · USPennsylvania State University · USIndiana University – Purdue University Indianapolis · USIndiana University School of Medicine

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI SABAN, DANIEL RAPHAEL · 1985 to 2025
$17.7M
Lipid Activated Nuclear Receptors in Age-Related Macular DegenerationR01EY020868 · NEI · DUKE UNIVERSITY · PI MALEK, GOLDIS · 2011 to 2015
$1.8M
NEI NIH HHS P30 EY005722NEI NIH HHS R01 EY020868
6 · The paper itself

Abstract

Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is a nuclear receptor that regulates differentiation, inflammation, lipid metabolism, extracellular matrix remodeling, and angiogenesis in multiple tissues. These pathways are also central to the pathogenesis of age-related macular degeneration (AMD), the leading cause of vision loss globally. With the goal of identifying signaling pathways that may be important in the development of AMD, we investigated the impact of PPARβ/δ activation on ocular tissues affected in the disease. PPARβ/δ is expressed and can be activated in AMD vulnerable cells, including retinal pigment epithelial (RPE) and choroidal endothelial cells. Further, PPARβ/δ knockdown modulates AMD-related pathways selectively. Specifically, genetic ablation of

Indexed as

AgedAnimalsCell LineCell MovementCell SurvivalElectroretinographyFemaleHumansMacaca mulattaMacular DegenerationMaleMiceMice, TransgenicMiddle AgedNeovascularization, PathologicPhenols(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acidGSK0660PhenolsPPAR-betaSulfhydryl CompoundsSulfonesThiazolesThiophenesage-related macular degenerationangiogenesischoroidal neovascularizationinflammationnuclear receptorsPPARβ/δ

Identifiers

PMID27622388
PMCPMC5076447
OpenAlexW2519280196

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.