SGLT2 inhibitors × kidney outcomes

SynthesisDiabetologia2016

Elevated serum magnesium associated with SGLT2 inhibitor use in type 2 diabetes patients: a meta-analysis of randomised controlled trials.

Huilin Tang et al.PubMed ↗Publisher ↗

  • Canagliflozin 100 mgno clear effectHigher serum magnesium levels, no range given.No ranges given.
  • Canagliflozin 300 mgno clear effectHigher serum magnesium levels, no range given.No ranges given.
  • Dapagliflozin 10 mgno clear effectHigher serum magnesium levels, no range given.No ranges given.
  • Empagliflozin 10 mgno clear effectHigher serum magnesium levels, no range given.No ranges given.

What the trial testedas reported · 15,309 people · 2016

No range given

Reported higher serum magnesium levels, no range given

+0.06mmol/l

canagliflozin 100 mg vs placebo, in patients without chronic kidney disease

As reported

difference 0.06 mmol/l, no interval

No range given

Reported higher serum magnesium levels, no range given

+0.09mmol/l

canagliflozin 300 mg vs placebo, in patients without chronic kidney disease

As reported

difference 0.09 mmol/l, no interval

No range given

Reported higher serum magnesium levels, no range given

+0.10mmol/l

dapagliflozin 10 mg vs placebo, in patients without chronic kidney disease

As reported

difference 0.1 mmol/l, no interval

No range given

Reported higher serum magnesium levels, no range given

+0.04mmol/l

empagliflozin 10 mg vs placebo, in patients without chronic kidney disease

As reported

difference 0.04 mmol/l, no interval

+2 more in the walkthrough ↓

Who was studied, and how

15,309people with type 2 diabetes, in this paper

Among patients without chronic kidney disease, the trial randomly assignedassigned by chance

canagliflozin 100 mg
placebo

Reported higher serum magnesium levels, no range given+0.06

randomised

Among patients without chronic kidney disease, the trial randomly assignedassigned by chance

canagliflozin 300 mg
placebo

Reported higher serum magnesium levels, no range given+0.09

randomised

the abstract, start to end

with placebo (canagliflozin: WMD 0.06 mmol/l for 100 mg and 0.09 mmol/l for 300 mg; dapagliflozin: WMD 0.1 mmol/l for 10 mg; empagliflozin: WMD 0.04 mmol/l for 10 mg and 0.07 mmol/l for 25 mg; and ipragliflozin: WMD 0.05 mmol/l for 50 mg).

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
Serum magnesium levelscanagliflozin 100 mg vs placebo, in patients without chronic kidney disease
0.06
Serum magnesium levelscanagliflozin 300 mg vs placebo, in patients without chronic kidney disease
0.09
Serum magnesium levelsdapagliflozin 10 mg vs placebo, in patients without chronic kidney disease
0.1
Serum magnesium levelsempagliflozin 10 mg vs placebo, in patients without chronic kidney disease
0.04
Serum magnesium levelsempagliflozin 25 mg vs placebo, in patients without chronic kidney disease
0.07
Serum magnesium levelsipragliflozin 50 mg vs placebo, in patients without chronic kidney disease
0.05
SGLT2 inhibitorsKidney outcomes
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