ArticleMolecular biology of the cell2016
The exocytic Rabs Ypt3 and Ypt2 regulate the early step of biogenesis of the spore plasma membrane in fission yeast.
Article in Molecular biology of the cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Article
- Membrane and organelle rearrangement during ascospore formation in budding yeast.Microbiology and molecular biology reviews : MMBR · 2024Review
- Emerging Roles of Exocyst Complex in Fungi: A Review.Journal of fungi (Basel, Switzerland) · 2024Review
- Sporulation: A response to starvation in the fission yeast Schizosaccharomyces pombe.MicrobiologyOpen · 2022Review
- An exocyst component, Sec5, is essential for ascospore formation inMycoscience · 2021Article
- The Fission Yeast RNA-Binding Protein Meu5 Is Involved in Outer Forespore Membrane Breakdown during Spore Formation.Journal of fungi (Basel, Switzerland) · 2020Article
- Meiosis-specific localization of the exocytic Rab Ypt2 in fission yeast.Small GTPases · 2020Article
- The fission yeast SPB component Dms1 is required to initiate forespore membrane formation and maintain meiotic SPB components.PloS one · 2018Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During fission yeast sporulation, a membrane compartment called the forespore membrane (FSM) is newly formed on the spindle pole body (SPB). The FSM expands by membrane vesicle fusion, encapsulates the daughter nucleus resulting from meiosis, and eventually matures into the plasma membrane of the spore. Although many of the genes involved in FSM formation have been identified, its molecular mechanism is not fully understood. Here a genetic screen for sporulation-deficient mutations identified Ypt3, a Rab-family small GTPase known to function in the exocytic pathway. The ypt3-ki8 mutant showed defects in both the initiation of FSM biogenesis and FSM expansion. We also show that a mutation in Ypt2, another Rab protein that may function in the same pathway as Ypt3, compromises the initiation of FSM formation. As meiosis proceeds, both GFP-Ypt3 and GFP-Ypt2 are observed at the SPB and then relocalize to the FSM. Their localizations at the SPB precede FSM formation and depend on the meiotic SPB component Spo13, a putative GDP/GTP exchange factor for Ypt2. Given that Spo13 is essential for initiating FSM formation, these results suggest that two exocytic Rabs, Ypt3 and Ypt2, regulate the initiation of FSM formation on the SPB in concert with Spo13.
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