ArticleEBioMedicine2016
Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality.
Open access · goldAbstract read
In one paragraph
Article in EBioMedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
4.8field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Research trends and hotspots on septic shock: a bibliometric study and visualization analysis.Frontiers in medicine · 2024Pooled it
- A genome-wide association study of survival in patients with sepsis.Critical care (London, England) · 2022Pooled it
- Association between the Lymphotoxin-BioMed research international · 2020Pooled it
- Adults with septic shock and extreme hyperferritinemia exhibit pathogenic immune variation.Genes and immunity · 2019Trial
- The molecular ICU: a primer on omics, informatics and the future of precision critical care.Critical care (London, England) · 2026Review
- Integration of Precision Medicine into ERAS Pathways: A Conceptual Framework, Current Feasibility and Challenges.Journal of personalized medicine · 2026Review
- Genome-wide association study of paediatric bacteraemia and sepsis.EBioMedicine · 2026Article
- A dataset of paired blood mRNA and microRNA sequencing across acute septic shock and recovery.Scientific data · 2026Article
- Genomic and integrative based progression biomarker discovery in adult sepsis: toward clinical stratification and precision medicine.Annals of intensive care · 2026Review
- Genetic associations in sepsis and ARDS.Frontiers in pharmacology · 2026Review
- The immunology of sepsis: translating new insights into clinical practice.Nature reviews. Nephrology · 2026Review
- Population-specific genetic-risk scores enable improved prediction of mortality within 28 days of sepsis onset: a retrospective Taiwanese cohort study.Journal of intensive care · 2025Article
- Application of whole-exome sequencing to predict inborn errors of immunity in pediatric severe infections and sepsis.Clinical and experimental immunology · 2025Observational
- Identifying sepsis susceptibility genes in post-surgical patients using an artificial intelligence approach.Frontiers in medicine · 2025Article
- The Global Burden of Sepsis and Septic Shock.Epidemiologia (Basel, Switzerland) · 2024Review
- eQTLs identify regulatory networks and drivers of variation in the individual response to sepsis.Cell genomics · 2024Article
- Use of Immune Profiling Panel to assess the immune response of septic patients for prediction of worsening as a composite endpoint.Scientific reports · 2024Article
- A Genome-Wide Association Study of Serum Metabolite Profiles in Septic Shock Patients.Critical care explorations · 2024Article
- The role of endotoxin in septic shock.Critical care (London, England) · 2023Review
- Subtypes and Mimics of Sepsis.Critical care clinics · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 8 institutions in 3 countries.
André ScheragIntegrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany; Research group Clinical Epidemiology, CSCC, Jena University Hospital, Jena, Germany. Electronic address: andre.scherag@med.uni-jena.de.
Franziska SchöneweckIntegrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany; Research group Clinical Epidemiology, CSCC, Jena University Hospital, Jena, Germany.
Miriam KesselmeierIntegrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany; Research group Clinical Epidemiology, CSCC, Jena University Hospital, Jena, Germany.
Stefan TaudienIntegrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany; Genome Analysis, Leibniz Institute on Aging - Fritz Lipmann Institute Jena, Germany.
Matthias PlatzerGenome Analysis, Leibniz Institute on Aging - Fritz Lipmann Institute Jena, Germany.
Marius FelderGenome Analysis, Leibniz Institute on Aging - Fritz Lipmann Institute Jena, Germany.
Christoph SponholzIntegrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany; Genome Analysis, Leibniz Institute on Aging - Fritz Lipmann Institute Jena, Germany; Department of Anesthesiology and Intensive Care Therapy, Jena University Hospital, Jena, Germany.
Anna RautanenWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Adrian V S HillWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Charles J HindsWilliam Harvey Research Institute, Barts and The London School of Medicine Queen Mary University of London, London, UK.
Hamid HossainUniversitätsklinikum Giessen und Marburg GmbH and Justus-Liebig-Universität Giessen, Giessen, Germany.
Norbert SuttorpCharité - Medizinische Klinik mit Schwerpunkt Infektiologie und Pneumologie, Berlin, Germany.
Oliver KurzaiIntegrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany; Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute Jena, Jena, Germany; Septomics Research Center Jena, Jena, Germany.
Hortense SlevogtIntegrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany; Septomics Research Center Jena, Jena, Germany.
Evangelos J Giamarellos-BourboulisIntegrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany; 4th Department of Internal Medicine National and Kapodistrian University of Athens, Athens, Greece.
Apostolos Armaganidis2nd Department of Critical Care Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Evelyn TripsClinical Trial Centre Leipzig, University of Leipzig, Leipzig, Germany.
Markus ScholzMedical Department, Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany; Medical Department, LIFE Research Center (Leipzig Interdisciplinary Research Cluster of Genetic Factors, Phenotypes and Environment), University of Leipzig, Leipzig, Germany.
Frank M BrunkhorstIntegrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany; Center for Clinical Studies, Jena University Hospital, Jena, Germany; Head of Paul-Martini-Clinical Sepsis Research Unit, Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.
Jena University Hospital · DELeibniz Institute on Aging - Fritz Lipmann Institute (FLI) · DECentre for Human Genetics · GBLeipzig University · DENational and Kapodistrian University of Athens · GRCharité - Universitätsmedizin Berlin · DEJustus-Liebig-Universität Gießen · DEQueen Mary University of London · GB
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is the dysregulated host response to an infection which leads to life-threatening organ dysfunction that varies by host genomic factors. We conducted a genome-wide association study (GWAS) in 740 adult septic patients and focused on 28day mortality as outcome. Variants with suggestive evidence for an association (p≤10
Indexed as
Genetic Predisposition to DiseaseGenetic VariationChromosome MappingCohort StudiesDisease ProgressionExomeFemaleGenome-Wide Association StudyGenomicsHigh-Throughput Nucleotide SequencingHumansMaleMortalityPolymorphism, Single NucleotidePrognosisQuantitative Trait LociExomeGenome-wide association studyHost responseMortalitySepsis
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.