Evidence map›Paper›PMID 27641304›Full record

ArticleCell stem cell2016

CD82 Is a Marker for Prospective Isolation of Human Muscle Satellite Cells and Is Linked to Muscular Dystrophies.

Matthew S Alexander, Anete Rozkalne, Alessandro Colletta, Janelle M Spinazzola, Samuel Johnson, Fedik Rahimov, Hui Meng, Michael W Lawlor, Elicia Estrella, Louis M Kunkel and 1 more

Open access · greenAbstract read
In one paragraph

Article in Cell stem cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 120 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Isolation and Culture of Primary Myoblasts from Humans and Mice.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Asthma and stem cell therapy.World journal of stem cells · 2025
    Review
  10. Article
  11. Article
  12. Building Haplotype-Resolved 3D Genome Maps of Chicken Skeletal Muscle.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  13. Article
  14. Mechanical Tensions Regulate Gene Expression in theInternational journal of molecular sciences · 2024
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Matthew S AlexanderDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA; The Stem Cell Program at Boston Children's Hospital, Boston, MA 02115, USA.
Anete RozkalneDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA.
Alessandro CollettaDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA; Boston University School of Medicine, Boston, MA 02215, USA.
Janelle M SpinazzolaDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA; The Stem Cell Program at Boston Children's Hospital, Boston, MA 02115, USA.
Samuel JohnsonDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA.
Fedik RahimovDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA; The Stem Cell Program at Boston Children's Hospital, Boston, MA 02115, USA.
Hui MengDivision of Pediatric Pathology, Department of Pathology and Laboratory Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Michael W LawlorDivision of Pediatric Pathology, Department of Pathology and Laboratory Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Elicia EstrellaDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA.
Louis M KunkelDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA; The Stem Cell Program at Boston Children's Hospital, Boston, MA 02115, USA; The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA 02115, USA.
Emanuela GussoniDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA 02115, USA; The Stem Cell Program at Boston Children's Hospital, Boston, MA 02115, USA. Electronic address: gussoni@enders.tch.harvard.edu.
Boston Children's Hospital · USMedical College of Wisconsin · USBoston University · US

Funding

Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2M
Modulation of Jagged1/Pitpna in DMD as a means of therapyR01AR064300 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI KUNKEL, LOUIS M · 2014 to 2023
$3.9M
C6ORF32, AN HDAC6-BINDING PROTEIN THAT REGULATES MYOBLAST DIFFERENTIATIONR01AR060317 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI GUSSONI, EMANUELA · 2011 to 2015
$1.9M
Tetraspanin CD82 in muscle satellite cells quiescence and differentiationR01AR069582 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI GUSSONI, EMANUELA · 2017 to 2022
$1.9M
NIAMS NIH HHS R01 AR060317NIAMS NIH HHS R01 AR064300NIAMS NIH HHS R01 AR069582NICHD NIH HHS U54 HD090255
6 · The paper itself

Abstract

Cell-surface markers for prospective isolation of stem cells from human skeletal muscle have been difficult to identify. Such markers would be powerful tools for studying satellite cell function during homeostasis and in pathogenesis of diseases such as muscular dystrophies. In this study, we show that the tetraspanin KAI/CD82 is an excellent marker for prospectively isolating stem cells from human fetal and adult skeletal muscle. Human CD82

Indexed as

AdultAnimalsAntigens, CDBiomarkersCD146 AntigenCell SeparationHEK293 CellsHumansImmunoprecipitationIntegrin alpha ChainsKangai-1 ProteinMice, SCIDMuscular DystrophiesMuscular Dystrophy, AnimalSarcoglycansSatellite Cells, Skeletal MuscleAntigens, CDBiomarkersCD146 Antigenintegrin alpha7Integrin alpha ChainsKangai-1 ProteinMCAM protein, humanSarcoglycans

Identifiers

PMID27641304
PMCPMC5135584
OpenAlexW2518802086

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.