ArticleNeurology2016
Cognitive decline following incident and preexisting diabetes mellitus in a population sample.
Article in Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Diabetes-Specific Dementia: A Structured Literature Review of Cognitive Assessment Methods.The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle SurgeonsPooled it
- Interactive effect of diabetes mellitus and subclinical MRI markers of cerebrovascular disease on cognitive decline and incident dementia: a memory-clinic study.Alzheimer's research & therapy · 2024Article
- Relationship between Cognitive Impairment and Depressive Symptoms with Somatosensory Functions in Diabetic and Non-Diabetic Older Adults and Its Impact on Quality of Life.Life (Basel, Switzerland) · 2023Article
- Lifestyle and Cognitive Decline in Community-Dwelling Stroke Survivors.Journal of Alzheimer's disease : JAD · 2022Article
- Cardiovascular and metabolic morbidity following spinal cord injury.The spine journal : official journal of the North American Spine Society · 2021Article
- Predictors of cognitive decline in a multi-racial sample of midlife women: A longitudinal study.Neuropsychology · 2021Article
- The Relation of Diabetes to Memory Function.Current neurology and neuroscience reports · 2020Review
- Stressful Life Events and Racial Disparities in Cognition Among Middle-Aged and Older Adults.Journal of Alzheimer's disease : JAD · 2020Article
- Disparities in diabetes-related multiple chronic conditions and mortality: The influence of race.Diabetes research and clinical practice · 2020Article
- Short height and poor education increase the risk of dementia in Nigerian type 2 diabetic women.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- Comprehensive transcriptomic analysis indicates brain regional specific alterations in type 2 diabetes.Aging · 2019Article
- Type 2 diabetes mellitus, brain atrophy and cognitive decline in older people: a longitudinal study.Diabetologia · 2019Article
- Associations of literacy with diabetes indicators in older adults.Journal of epidemiology and community health · 2019Article
- Locus Coeruleus Degeneration Induces Forebrain Vascular Pathology in a Transgenic Rat Model of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2019Article
- Cognitive decline is related to high blood glucose levels in older Chinese adults with the ApoE ε3/ε3 genotype.Translational neurodegeneration · 2019Article
- Changes of glucose levels precede dementia in African-Americans with diabetes but not in Caucasians.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Article
- The chicken or the egg? Does glycaemic control predict cognitive function or the other way around?Diabetologia · 2018Article
- Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo examine if incident and preexisting diabetes mellitus (DM) were associated with cognitive decline among African Americans (AAs) and European Americans (EAs).
methodsBased on a prospective study of 7,740 older adults (mean age 72.3 years, 64% AA, 63% female), DM was ascertained by hypoglycemic medication use and Medicare claims during physician or hospital visits, and cognition by performance on a brief battery for executive functioning, episodic memory, and Mini-Mental State Examination (MMSE). Decline in composite and individual tests among those with incident DM, with preexisting DM, and without DM was studied using a linear mixed effects model with and without change point.
resultsAt baseline, 737 (15%) AAs and 269 (10%) EAs had preexisting DM. Another 721 (17%) AAs and 289 (12%) EAs had incident DM in old age. Following incident DM, cognitive decline increased by 36% among AAs and by 40% among EAs compared to those without DM. No significant difference was observed between AAs and EAs (p = 0.64). However, cognitive decline increased by 17% among AAs with preexisting DM compared to those without DM, but no increased decline was observed among EAs with preexisting DM. In secondary analyses, faster decline in executive functioning and episodic memory was observed following incident DM.
conclusionsIn old age, faster cognitive decline was present among AAs and EAs following incident DM, compared to cognitive decline prior to DM, and among those without DM. This underscores the need for stronger prevention and control of DM in old age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.