Evidence map›Paper›PMID 27655810›Full record

ArticlePhysiological reports2016

Gender differences in V˙O2 and HR kinetics at the onset of moderate and heavy exercise intensity in adolescents.

Nicola Lai, Alessandro Martis, Alfredo Belfiori, Fatima Tolentino-Silva, Melita M Nasca, James Strainic, Marco E Cabrera

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Factors Affecting V̇OScandinavian journal of medicine & science in sports · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Changes in VOFrontiers in physiology · 2019
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Nicola LaiDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio Department of Pediatrics Cardiology, Case Western Reserve University, Cleveland, Ohio Center for Modeling Integrated Metabolic Systems, Cleveland, Ohio Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, Virginia Biomedical Engineering Institute, Old Dominion University, Norfolk, Virginia nlai@odu.edu.
Alessandro MartisDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.
Alfredo BelfioriDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.
Fatima Tolentino-SilvaCenter for Modeling Integrated Metabolic Systems, Cleveland, Ohio.
Melita M NascaDepartment of Pediatrics Cardiology, Case Western Reserve University, Cleveland, Ohio Rainbow Babies and Children's Hospital, Cleveland, Ohio.
James StrainicDepartment of Pediatrics Cardiology, Case Western Reserve University, Cleveland, Ohio Rainbow Babies and Children's Hospital, Cleveland, Ohio.
Marco E CabreraDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio Department of Pediatrics Cardiology, Case Western Reserve University, Cleveland, Ohio Center for Modeling Integrated Metabolic Systems, Cleveland, Ohio Rainbow Babies and Children's Hospital, Cleveland, Ohio.
Case Western Reserve University · USRainbow Babies & Children's Hospital · USMetabolic Modeling Services (New Zealand) · NZ

Funding

CORE--SYSTEM MODELING INTEGRATIONP50GM066309 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI SAIDEL, GERALD M · 2002 to 2006
$11.4M
Systems Biology Investigation of Muscle Exercise Metabolism in DiabetesK25AR057206 · NIAMS · OLD DOMINION UNIVERSITY · PI LAI, NICOLA · 2011 to 2015
$593k
NIAMS NIH HHS K25 AR057206NIGMS NIH HHS P50 GM066309
6 · The paper itself

Abstract

The majority of the studies on V˙O2 kinetics in pediatric populations investigated gender differences in prepubertal children during submaximal intensity exercise, but studies are lacking in adolescents. The purpose of this study was to test the hypothesis that gender differences exist in the V˙O2 and heart rate (HR) kinetic responses to moderate (M) and heavy (H) intensity exercise in adolescents. Twenty-one healthy African-American adolescents (9 males, 15.8 ± 1.1 year; 12 females, 15.7 ± 1 year) performed constant work load exercise on a cycle ergometer at M and H. The V˙O2 kinetics of the male group was previously analyzed (Lai et al., Appl. Physiol. Nutr. Metab. 33:107-117, 2008b). For both genders, V˙O2 and HR kinetics were described with a single exponential at M and a double exponential at H. The fundamental time constant (τ

Indexed as

adolescentsAfrican Americanexerciseheart ratekineticsmodelingpulmonary O2 uptake

Identifiers

PMID27655810
PMCPMC5037918
OpenAlexW2521827058

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.