Evidence map›Paper›PMID 27659126›Full record

Trial reportNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2017

Effect of high-protein meals during hemodialysis combined with lanthanum carbonate in hypoalbuminemic dialysis patients: findings from the FrEDI randomized controlled trial.

Connie M Rhee, Amy S You, Tara Koontz Parsons, Amanda R Tortorici, Rachelle Bross, David E St-Jules, Jennie Jing, Martin L Lee, Debbie Benner, Csaba P Kovesdy and 3 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03947710 (Acute Effect of Protein Intake During Dialysis on Intradialytic Blood Pressure, 24-hour Ambulatory Blood Pressure and Arterial Stiffness Indices in Maintenance Hemodialysis Patients.), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03947710 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Acute Effect of Protein Intake During Dialysis on Intradialytic Blood Pressure, 24-hour Ambulatory Blood Pressure and Arterial Stiffness Indices in Maintenance Hemodialysis Patients.

TypeinterventionalSponsorAristotle University Of ThessalonikiRan2019 to 2020Enrolled45ConditionsEnd Stage Renal Disease, Hypotension During Dialysis, Protein Malnutrition, Arterial SclerosisArmsHigh-protein meals, Low- protein meals, No meals
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. The Role of Precision Nutrition in Kidney Disease.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Review
  5. Phosphate-latest news and ongoing trials.Clinical kidney journal · 2026
    Review
  6. Article
  7. Dietary Phosphorus and Metabolic Health in CKD and ESKD.Clinical journal of the American Society of Nephrology : CJASN · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Review
  14. Review
  15. Review
  16. Dietary Acid-Base Balance in High-Performance Athletes.International journal of environmental research and public health · 2020
    Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 1 country.

Connie M RheeHarold Simmons Center for Chronic Disease Research and Epidemiology, University of California Irvine School of Medicine, Orange, CA, USA.
Amy S YouHarold Simmons Center for Chronic Disease Research and Epidemiology, University of California Irvine School of Medicine, Orange, CA, USA.
Tara Koontz ParsonsLos Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.
Amanda R TortoriciHarold Simmons Center for Chronic Disease Research and Epidemiology, University of California Irvine School of Medicine, Orange, CA, USA.
Rachelle BrossLos Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.
David E St-JulesCenter for Healthful Behavior Change, New York University School of Medicine, New York, NY, USA.
Jennie JingHarold Simmons Center for Chronic Disease Research and Epidemiology, University of California Irvine School of Medicine, Orange, CA, USA.
Martin L LeeUCLA Fielding School of Public Health, Los Angeles, CA, USA.
Debbie BennerDaVita Inc., El Segundo, CA, USA.
Csaba P KovesdyDivision of Nephrology, University of Tennessee Health Science Center, Memphis, TN, USA.
Rajnish MehrotraKidney Research Institute and Harborview Medical Center, Division of Nephrology, University of Washington, Seattle, WA, USA.
Joel D KoppleUCLA Fielding School of Public Health, Los Angeles, CA, USA.
Kamyar Kalantar-ZadehHarold Simmons Center for Chronic Disease Research and Epidemiology, University of California Irvine School of Medicine, Orange, CA, USA.
University of California, Irvine · USAPLA Health · USFielding Graduate University · USGalorath (United States) · USHarbor–UCLA Medical Center · USNew York University · USThe Lundquist Institute · USUCLA Medical Center · USUniversity of Tennessee Health Science Center · USUniversity of Washington · US

Funding

MALNUTRITION, DIET AND RACIAL DISPARITIES IN CKDK24DK091419 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI KALANTAR-ZADEH, KAMYAR · 2011 to 2020
$1.8M
NIDDK NIH HHS K24 DK091419
6 · The paper itself

Abstract

backgroundInadequate protein intake and hypoalbuminemia, indicators of protein-energy wasting, are among the strongest mortality predictors in hemodialysis patients. Hemodialysis patients are frequently counseled on dietary phosphorus restriction, which may inadvertently lead to decreased protein intake. We hypothesized that, in hypoalbuminemic hemodialysis patients, provision of high-protein meals during hemodialysis combined with a potent phosphorus binder increases serum albumin without raising phosphorus levels.

methodsWe conducted a randomized controlled trial in 110 adults undergoing thrice-weekly hemodialysis with serum albumin <4.0 g/dL recruited between July 2010 and October 2011 from eight Southern California dialysis units. Patients were randomly assigned to receive high-protein (50-55 g) meals during dialysis, providing 400-500 mg phosphorus, combined with lanthanum carbonate versus low-protein (<1 g) meals during dialysis, providing <20 mg phosphorus. Prescribed nonlanthanum phosphorus binders were continued over an 8-week period. The primary composite outcome was a rise in serum albumin of ≥0.2 g/dL while maintaining phosphorus between 3.5-<5.5 mg/dL. Secondary outcomes included achievement of the primary outcome's individual endpoints and changes in mineral and bone disease and inflammatory markers.

resultsAmong 106 participants who satisfied the trial entrance criteria, 27% ( n = 15) and 12% ( n = 6) of patients in the high-protein versus low-protein hemodialysis meal groups, respectively, achieved the primary outcome (intention-to-treat P-value = 0.045). A lower proportion of patients in the high-protein versus low-protein intake groups experienced a meaningful rise in interleukin-6 levels: 9% versus 31%, respectively (P = 0.009). No serious adverse events were observed.

conclusionIn hypoalbuminemic hemodialysis patients, high-protein meals during dialysis combined with lanthanum carbonate are safe and increase serum albumin while controlling phosphorus.

Indexed as

Renal DialysisBone DiseasesDietary ProteinsFemaleHumansHypoalbuminemiaLanthanumMaleMiddle AgedPhosphorusDietary ProteinsLanthanumlanthanum carbonatePhosphorushemodialysishigh-proteinhyperphosphatemiahypoalbuminemiaprotein-energy wasting

Identifiers

PMID27659126
PMCPMC6251566
OpenAlexW2523451800

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.