ArticleCardiovascular diabetology2016
Cholesterol remnants and triglycerides are associated with decreased myocardial function in patients with type 2 diabetes.
Article in Cardiovascular diabetology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Predicting heart failure in asymptomatic diabetes: derivation and internal validation of a clinical prediction model for early detection of diabetic cardiomyopathy.Frontiers in endocrinology · 2026Article
- Relationship Between Remnant Cholesterol and Risk of Heart Failure in a Community Population Without Cardiovascular Disease: Results of the China Patient-Centered Evaluative Assessment of Cardiac Events Million Persons Project.Journal of the American Heart Association · 2025Observational
- Pemafibrate and cardiac reverse remodeling in patients with systolic heart failure receiving guideline-directed medical therapy.Journal of cardiology cases · 2025Article
- Predictive value of remnant cholesterol for left ventricular hypertrophy and prognosis in hypertensive patients with heart failure: a prospective study.Lipids in health and disease · 2024Article
- Assessing right ventricular peak strain in myocardial infarction patients with mitral regurgitation by cardiac magnetic resonance feature tracking.Quantitative imaging in medicine and surgery · 2024Article
- Acute and Subchronic Toxicological Study of the Cocktail Extract fromJournal of toxicology · 2024Article
- Role of remnant cholesterol in the relationship between physical activity and diabetes mellitus: an intermediary analysis.Frontiers in public health · 2024Article
- Remnant Cholesterol in Young Adulthood Is Associated With Left Ventricular Remodeling and Dysfunction in Middle Age: The CARDIA Study.Circulation. Cardiovascular imaging · 2023Article
- Effect of hypertriglyceridemia on left ventricular global longitudinal strain in patients with coronary heart disease in Jilin Province, China: a cross-sectional study.Frontiers in cardiovascular medicine · 2023Article
- Modified Haller index validation and correlation with left ventricular strain in a cohort of subjects with obesity and without overt heart disease.Internal and emergency medicine · 2022Article
- Remnant Cholesterol and Its Visit-to-Visit Variability Predict Cardiovascular Outcomes in Patients With Type 2 Diabetes: Findings From the ACCORD Cohort.Diabetes care · 2022Article
- The Effects of Calculated Remnant-Like Particle Cholesterol on Incident Cardiovascular Disease: Insights from a General Chinese Population.Journal of clinical medicine · 2021Article
- Remnant Cholesterol is an Independent Predictor of New-Onset Diabetes: A Single-Center Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits.Clinical epigenetics · 2020Article
- A Vegan Athlete's Heart-Is It Different? Morphology and Function in Echocardiography.Diagnostics (Basel, Switzerland) · 2020Article
- The longitudinal association of remnant cholesterol with cardiovascular outcomes in patients with diabetes and pre-diabetes.Cardiovascular diabetology · 2020Article
- Epicardial adipose tissue predicts incident cardiovascular disease and mortality in patients with type 2 diabetes.Cardiovascular diabetology · 2019Article
- Burden of Uncontrolled Metabolic Risk Factors and Left Ventricular Structure and Function in Patients With Type 2 Diabetes Mellitus.Journal of the American Heart Association · 2018Article
- Omega-3 polyunsaturated fatty acids supplementation in patients with diabetes and cardiovascular disease risk: does dose really matter?Cardiovascular diabetology · 2018Article
- Overweight and obesity impair left ventricular systolic function as measured by left ventricular ejection fraction and global longitudinal strain.Cardiovascular diabetology · 2018Observational
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, genetic studies have suggested a causal relationship between cholesterol remnants and ischemic heart disease. We aimed to determine whether cholesterol remnants and its marker, triglyceride levels, are associated with cardiac function as determined by sensitive echocardiographic measures in a population of patients with type 2 diabetes.
methodsComprehensive echocardiography including 2D-speckle tracking echocardiography was performed on a representative sample of 924 patients with type 2 diabetes-730 of whom were treated with statins. These were recruited from two large secondary care centers.
resultsIn multivariable analyses, triglycerides and cholesterol remnants were not associated with left ventricular ejection fraction, but with subtle measures of systolic function, including global longitudinal strain by speckle tracking and longitudinal displacement by tissue Doppler echocardiography: global longitudinal strain [0.33 % (0.14), p = 0.02 per doubling in cholesterol remnants and 0.28 % (0.13), p = 0.03 per doubling in triglyceride levels] and with longitudinal displacement [-0.25 mm (0.10), p = 0.01 per doubling in cholesterol remnants and -0.25 mm (0.09), p = 0.005 per doubling in triglyceride levels]. Subgroup analyses of patients receiving statin therapy and patients without known heart disease revealed similar results, but the association was not present in patients with known heart disease.
conclusionIn patients with type 2 diabetes, subtle decrease in left ventricular function is present with increasing levels of cholesterol remnants and triglyceride levels indicating an effect of these on cardiac function that is not detectable by conventional echocardiography.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.