ArticleFly2017
Control of non-apoptotic nurse cell death by engulfment genes in Drosophila.
Article in Fly, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Review
- Ecdysone regulates phagocytic cell fate of epithelial cells in developing Drosophila eggs.The Journal of cell biology · 2025Article
- GATA factor Serpent promotes phagocytosis in non-professional phagocytes during Drosophila oogenesis.Development (Cambridge, England) · 2025Article
- Article
- Sacrificing cells of the cyst: non-apoptotic cell death in germline cysts via acidification.Frontiers in cell death · 2025Article
- Single-nucleus atlas of the Artemia female reproductive system suggests germline repression of the Z chromosome.PLoS genetics · 2024Article
- Finishing the egg.Genetics · 2024Article
- Activated Src kinase promotes cell cannibalism in Drosophila.The Journal of cell biology · 2023Article
- Eya-controlled affinity between cell lineages drives tissue self-organization during Drosophila oogenesis.Nature communications · 2022Article
- βPS-Integrin acts downstream of Innexin 2 in modulating stretched cell morphogenesis in the Drosophila ovary.G3 (Bethesda, Md.) · 2021Article
- An RNAi screen of the kinome in epithelial follicle cells of the Drosophila melanogaster ovary reveals genes required for proper germline death and clearance.G3 (Bethesda, Md.) · 2021Article
- Cell death in animal development.Development (Cambridge, England) · 2020Review
- A single-cell atlas of adult Drosophila ovary identifies transcriptional programs and somatic cell lineage regulating oogenesis.PLoS biology · 2020Article
- Review
- Somatic support cells regulate germ cell survival through the Baz/aPKC/Par6 complex.Development (Cambridge, England) · 2019Article
- I Spy in the Developing Fly a Multitude of Ways to Die.Journal of developmental biology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Programmed cell death occurs as a normal part of oocyte development in Drosophila. For each egg that is formed, 15 germline-derived nurse cells transfer their cytoplasmic contents into the oocyte and die. Disruption of apoptosis or autophagy only partially inhibits the death of the nurse cells, indicating that other mechanisms significantly contribute to nurse cell death. Recently, we demonstrated that the surrounding stretch follicle cells non-autonomously promote nurse cell death during late oogenesis and that phagocytosis genes including draper, ced-12, and the JNK pathway are crucial for this process. When phagocytosis genes are inhibited in the follicle cells, events specifically associated with death of the nurse cells are impaired. Death of the nurse cells is not completely blocked in draper mutants, suggesting that other engulfment receptors are involved. Indeed, we found that the integrin subunit, αPS3, is enriched on stretch follicle cells during late oogenesis and is required for elimination of the nurse cells. Moreover, double mutant analysis revealed that integrins act in parallel to draper. Death of nurse cells in the Drosophila ovary is a unique example of programmed cell death that is both non-apoptotic and non-cell autonomously controlled.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.