Trial reportThe Journal of physiology2017
Local depletion of glycogen with supramaximal exercise in human skeletal muscle fibres.
Trial report in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Running Assessed Maximal Oxygen Uptake Increases with Participant Classification Framework Tier in Overall Cross-Country Skiing Performance: A Systematic Review with Meta-regressions.Sports medicine - open · 2026Pooled it
- Carbohydrate Storage and Supplementation Strategies for Peak Performance in Cross-Country Skiing.Scandinavian journal of medicine & science in sports · 2026Review
- Dynamics of muscle glycogen increase in brachial and thigh muscles with carbohydrate loading.European journal of applied physiology · 2025Article
- Muscle Metabolism and Performance During Simulated Peak-Intensity Periods Occurring Early and Late in a Soccer-Specific Exercise Protocol in Well-Trained Male Players.Scandinavian journal of medicine & science in sports · 2025Article
- In vivo imaging of glycogen in human muscle.Nature communications · 2024Article
- Mitochondrial Redox Status Regulates Glycogen Metabolism via Glycogen Phosphorylase Activity.Antioxidants (Basel, Switzerland) · 2024Article
- Effect of Low vs. High Carbohydrate Intake after Glycogen-Depleting Workout on Subsequent 1500 m Run Performance in High-Level Runners.Nutrients · 2024Article
- Peak Week Carbohydrate Manipulation Practices in Physique Athletes: A Narrative Review.Sports medicine - open · 2024Review
- The molecular athlete: exercise physiology from mechanisms to medals.Physiological reviews · 2023Review
- Neurotoxins Acting at Synaptic Sites: A Brief Review on Mechanisms and Clinical Applications.Toxins · 2022Review
- Fibre type- and localisation-specific muscle glycogen utilisation during repeated high-intensity intermittent exercise.The Journal of physiology · 2022Article
- Interlink Between Physiological and Biomechanical Changes in the Swim-to-Cycle Transition in Triathlon Events: A Narrative Review.Sports medicine - open · 2022Review
- State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions.Comprehensive Physiology · 2022Article
- Effects of Diet, Lifestyle, Chrononutrition and Alternative Dietary Interventions on Postprandial Glycemia and Insulin Resistance.Nutrients · 2022Review
- Nutritional approaches to counter performance constraints in high-level sports competition.Experimental physiology · 2021Review
- Muscle Glycogen Metabolism and High-Intensity Exercise Performance: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2021Review
- Myocardial subcellular glycogen distribution and sarcoplasmic reticulum CaJournal of muscle research and cell motility · 2021Article
- Contractile Properties of MHC I and II Fibers From Highly Trained Arm and Leg Muscles of Cross-Country Skiers.Frontiers in physiology · 2021Article
- Effects of Acute Exercise and Training on the Sarcoplasmic Reticulum CaFrontiers in physiology · 2020Article
- Energy system contribution during competitive cross-country skiing.European journal of applied physiology · 2019Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key pointsGlycogen is stored in local spatially distinct compartments within skeletal muscle fibres and is the main energy source during supramaximal exercise. Using quantitative electron microscopy, we show that supramaximal exercise induces a differential depletion of glycogen from these compartments and also demonstrate how this varies with fibre types. Repeated exercise alters this compartmentalized glycogen depletion. The results obtained in the present study help us understand the muscle metabolic dynamics of whole body repeated supramaximal exercise, and suggest that the muscle has a compartmentalized local adaptation to repeated exercise, which affects glycogen depletion. ABSTRACT: Skeletal muscle glycogen is heterogeneously distributed in three separated compartments (intramyofibrillar, intermyofibrillar and subsarcolemmal). Although only constituting 3-13% of the total glycogen volume, the availability of intramyofibrillar glycogen is of particular importance to muscle function. The present study aimed to investigate the depletion of these three subcellular glycogen compartments during repeated supramaximal exercise in elite athletes. Ten elite cross-country skiers (aged 25 ± 4 years, V̇O2 max : 65 ± 4 ml kg
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.