ArticleHypertension (Dallas, Tex. : 1979)2016
Agonistic Autoantibodies to the Angiotensin II Type 1 Receptor Enhance Angiotensin II-Induced Renal Vascular Sensitivity and Reduce Renal Function During Pregnancy.
Article in Hypertension (Dallas, Tex. : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- Increased ATCell death & disease · 2020Trial
- The plasma metabolome of women in early pregnancy differs from that of non-pregnant women.PloS one · 2019Trial
- Sex differences in the developmental programming of cardiovascular and renal risk across the lifespan.American journal of physiology. Renal physiology · 2026Review
- AT1-AA induced hypertension during pregnancy contributes to developmental programming of hypertension in female offspring.Journal of reproductive immunology · 2025Article
- Angiotensin II type-1 receptor autoantibodies and effects in neonates of women with preeclampsia.BMC pregnancy and childbirth · 2025Article
- Placental ischemia-upregulated angiotensin II type 1 receptor in hypothalamic paraventricular nucleus contributes to hypertension in rat.Pflugers Archiv : European journal of physiology · 2024Article
- The role of T cell stimulated agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA) in mediating multiorgan dysfunction in IL-17 induced hypertension during pregnancy.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024Article
- AT1-AA Is Produced in Offspring in Response to Placental Ischemia and Is Lowered by B-Cell Depletion Without Compromising Overall Offspring Health.Journal of the American Heart Association · 2024Article
- The role of immune cells and mediators in preeclampsia.Nature reviews. Nephrology · 2023Review
- AT1-AA Infusion during Pregnancy Impairs CBF Autoregulation Postpartum.International journal of cerebrovascular disease and stroke · 2023Article
- Inhibition of the ATAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Association of maternal angiotensin II type 1 and type 2 receptor combination genotypes with susceptibility to early-onset preeclampsia.Journal of human hypertension · 2022Article
- Empagliflozin Ameliorates Preeclampsia and Reduces Postpartum Susceptibility to Adriamycin in a Mouse Model Induced by Angiotensin Receptor Agonistic Autoantibodies.Frontiers in pharmacology · 2022Article
- Angiotensin II type 1 receptor agonistic autoantibody blockade improves postpartum hypertension and cardiac mitochondrial function in rat model of preeclampsia.Biology of sex differences · 2021Article
- Association of Angiotensin II Type 1 Receptor Agonistic Autoantibodies With Outcomes in Patients With Acute Aortic Dissection.JAMA network open · 2021Article
- The Role of Mitochondrial Dysfunction in Preeclampsia: Causative Factor or Collateral Damage?American journal of hypertension · 2021Review
- Investigation of interleukin-2-mediated changes in blood pressure, fetal growth restriction, and innate immune activation in normal pregnant rats and in a preclinical rat model of preeclampsia.Biology of sex differences · 2021Article
- Advances in biomarker development and potential application for preeclampsia based on pathogenesis.European journal of obstetrics & gynecology and reproductive biology: X · 2021Review
- Tumor necrosis factor alpha (TNF-α) blockade improves natural killer cell (NK) activation, hypertension, and mitochondrial oxidative stress in a preclinical rat model of preeclampsia.Hypertension in pregnancy · 2020Article
- Local angiotensin-(1-7) administration improves microvascular endothelial function in women who have had preeclampsia.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Preeclamptic women produce agonistic autoantibodies to the angiotensin II type 1 receptor (AT1-AA) and exhibit increased blood pressure (mean arterial pressure), vascular sensitivity to angiotensin II (ANG II), and display a decrease in renal function. The objective of this study was to examine the renal hemodynamic changes during pregnancy in the presence of AT1-AAs with or without a slow pressor dose of ANG II. In this study, mean arterial pressure was elevated in all pregnant rats treated with ANG II with or without AT1-AA. Glomerular filtration rate was reduced from 1.90±0.16 mL/min in normal pregnant (NP) to 1.20±0.08 in ANG II+AT1-AA rats. Renal blood flow was decreased in ANG II+AT1-AA versus NP rats to 7.4±1.09 versus 15.4±1.75 mL/min. Renal vascular resistance was drastically increased between ANG II+AT1-AA versus NP rats (18.4±2.91 versus 6.4±0.77 mm Hg/mL per minute). Isoprostane excretion was increased by 3.5-fold in ANG II+AT1-AA versus NP (1160±321 versus 323±52 pg/mL). In conclusion, ANG II and AT1-AA together significantly decrease glomerular filtration rate by 37% and renal blood flow by 50% and caused a 3-fold increase in renal vascular resistance and isoprostane levels versus NP rats. These data indicate the importance of AT1-AAs to enhance ANG II-induced renal vasoconstriction and reduce renal function as mechanisms to cause hypertension as observed during preeclampsia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.