ReviewExperimental physiology2016
Pleiotropic function of TRPV4 ion channels in the central nervous system.
Review in Experimental physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- 25+ Years of TRPV4: From Discovery to Translational Horizons.Research square · 2026Article
- Article
- Small molecule inhibition rescues the skeletal dysplasia phenotype of Trpv4 mutant mice.JCI insight · 2026Article
- TRPV3 channel activity helps cortical neurons stay active during fever.bioRxiv : the preprint server for biology · 2025Article
- Mechanosensitive ion channels and inflammation: key links in cellular signal transduction.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- The role of TRPV4 in acute sleep deprivation-induced memory impairment: Mechanisms of calcium dysregulation and synaptic plasticity disruption.Cell insight · 2025Article
- CaActa physiologica (Oxford, England) · 2025Article
- TRP channels in epileptogenesis: calcium dysregulation mechanisms and pharmacological targeting strategies.Frontiers in molecular neuroscience · 2025Review
- A QUARTER CENTURY OF CALCIUM-PERMEABLE ION CHANNEL, TRPV4: PERSPECTIVES ON EXPRESSION AND FUNCTION IN ENDOTHELIAL CELLS-TIME TO TRANSLATE.Transactions of the American Clinical and Climatological Association · 2025Review
- Involvement of the Transient Receptor Channels in Preclinical Models of Musculoskeletal Pain.Current neuropharmacology · 2024Review
- Cellular signaling pathways in the nervous system activated by various mechanical and electromagnetic stimuli.Frontiers in molecular neuroscience · 2024Review
- Transient Receptor Potential Vanilloid 4-Dependent Microglial Function in Myelin Injury and Repair.International journal of molecular sciences · 2023Article
- Extremely Low-Frequency Electromagnetic Stimulation (ELF-EMS) Improves Neurological Outcome and Reduces Microglial Reactivity in a Rodent Model of Global Transient Stroke.International journal of molecular sciences · 2023Article
- Astrocytic TRPV4 Channels and Their Role in Brain Ischemia.International journal of molecular sciences · 2023Review
- Inhibition of Trpv4 rescues circuit and social deficits unmasked by acute inflammatory response in a Shank3 mouse model of Autism.Molecular psychiatry · 2022Article
- Spinal cord dorsal horn sensory gate in preclinical models of chemotherapy-induced painful neuropathy and contact dermatitis chronic itch becomes less leaky withFrontiers in molecular neuroscience · 2022Article
- Thermosensitive receptors in neural stem cells link stress-induced hyperthermia to impaired neurogenesis via microglial engulfment.Science advances · 2021Article
- Emerging Role of Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channel in Acute and Chronic Itch.International journal of molecular sciences · 2021Review
- TRPV Protein Family-From Mechanosensing to Cancer Invasion.Biomolecules · 2021Review
- Impaired neurite development and mitochondrial dysfunction associated with calcium accumulation in dopaminergic neurons differentiated from the dental pulp stem cells of a patient with metatropic dysplasia.Biochemistry and biophysics reports · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
NEW
findingsWhat is the topic of this review? In this concise review, we highlight insights into the role of transient receptor potential, vanilloid type 4 (TRPV4) ion channels in the CNS, results that have been contributed over the last 16 years since the initial discovery of the channel. What advances does it highlight? TRPV4 has been found to function in neurons, astroglia and microglia, both in physiological (e.g. astrocytic neurovascular coupling, neuronal membrane potential at physiological temperature) and in pathological conditions (e.g. mechanical trauma), so far recorded as exciting findings in need of more in-depth mechanistic clarification. Transient receptor potential, vanilloid type 4 (TRPV4) ion channels are osmo-mechano-TRP channels, with pleiotropic function and expression in many different types of tissues and cells. They have also been found to be involved in pain and inflammation. Studies have focused on the role of TRPV4 in peripheral sensory neurons, but its expression and function in central nervous glial cells and neurons has also been documented. In this overview, based on the senior author's (WL) lecture at the recent recent joint meeting of APS/The Physiological Society in Dublin, we concisely review evidence of TRPV4 expression and function in the CNS and how TRPV4 function can be modulated for therapeutic benefit of neuropsychiatric disorders. Novel TRPV4-inhibitory compounds developed recently in the authors' laboratory are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.