Evidence map›Paper›PMID 27727196›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2016

A Tumor-Specific Prognostic Long Non-Coding RNA Signature in Gastric Cancer.

Wu Ren, Jian Zhang, Wei Li, Zongcheng Li, Shuofeng Hu, Jian Suo, Xiaomin Ying

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Wu RenDepartment of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, Jilin, China (mainland).
Jian Zhang, Beijing Institute of Basic Medical Sciences, Beijing, China (mainland).
Wei LiDepartment of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, Jilin, China (mainland).
Zongcheng Li, Beijing Institute of Basic Medical Sciences, Beijing, China (mainland).
Shuofeng Hu, Beijing Institute of Basic Medical Sciences, Beijing, China (mainland).
Jian SuoDepartment of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, Jilin, China (mainland).
Xiaomin Ying, Beijing Institute of Basic Medical Sciences, Beijing, China (mainland).
Institute of Basic Medical Sciences of the Chinese Academy of Medical SciencesJilin University · CNFirst Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND Aberrant expression of long non-coding RNAs (lncRNAs) is associated with prognosis of gastric cancer, some of which could be further evaluated as potential biomarkers. In this study, we attempted to identify a specific lncRNA signature to predict the prognosis of gastric cancer. MATERIAL AND METHODS The genome-wide lncRNA expression in the high-throughput RNA-sequencing data was retrieved from the Cancer Genome Atlas (TCGA). Differential expression of lncRNAs was identified using the Limma package. Survival analysis was conducted by use of univariate and multivariate Cox regression models. Functional enrichment analysis of lncRNAs was based on co-expressed mRNAs. DAVID was used to perform gene ontology and KEGG pathway analysis. RESULTS A total of 452 differentially expressed lncRNAs between gastric cancer and matched normal tissues were screened, of which 76 lncRNAs were identified to be gastric cancer-specific from a pan-cancer analysis of 12 types of human cancer. Among these 76 gastric cancer-specific lncRNAs, 5 lncRNAs (CTD-2616J11.14, RP1-90G24.10, RP11-150O12.3, RP11-1149O23.2, and MLK7-AS1) were significantly associated with the overall survival of patients with gastric cancer. A gastric cancer-specific 5-lncRNA signature was deduced to divide the patients into high- and low-risk groups with significantly different survival times (P<0.0001). Multivariate Cox regression analysis showed that this 5-lncRNA signature was an independent predictor of prognosis. Functional enrichment analysis of the 5 lncRNAs showed that they were mainly involved in DNA replication, mitotic cell cycle, programmed cell death, and RNA splicing. CONCLUSIONS Our results suggest that this tumor-specific lncRNA signature may be clinically useful in the prediction of gastric cancer prognosis.

Indexed as

AdultAgedBiomarkers, TumorFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateMaleMiddle AgedPrognosisRNA, Long NoncodingRNA, MessengerStomach NeoplasmsSurvival AnalysisBiomarkers, TumorRNA, Long NoncodingRNA, Messenger

Identifiers

PMID27727196
PMCPMC5072383
OpenAlexW2530583329

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.