ArticleNeuropsychiatric disease and treatment2016
Type 2 diabetes mellitus might be a risk factor for mild cognitive impairment progressing to Alzheimer's disease.
Article in Neuropsychiatric disease and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Type 2 Diabetes Mellitus Is Associated with the Risk of Cognitive Impairment: a Meta-Analysis.Journal of molecular neuroscience : MN · 2019Pooled it
- Article
- A prediction nomogram for mild cognitive impairment in type 2 diabetes mellitus based on the Chinese visceral adiposity index.Scientific reports · 2025Article
- Sleep habits, brain functional networks, and type 2 diabetes risk: cohort studies from North American and Asian populations and mediating Mendelian randomization analyses.Diabetology & metabolic syndrome · 2025Article
- Associations Between Diabetes Mellitus and Neurodegenerative Diseases.International journal of molecular sciences · 2025Review
- Is a body mass index of less than 18.5 kg/mBMJ open · 2024Article
- Mediation effect of cognitive impairment for the relationship of type 2 diabetes mellitus with mortality among elderly individuals.Frontiers in endocrinology · 2024Article
- Molecular and neural roles of sodium-glucose cotransporter 2 inhibitors in alleviating neurocognitive impairment in diabetic mice.Psychopharmacology · 2023Article
- Exploration and Clinical Verification of the Blood Co-Expression Genes of Type 2 Diabetes Mellitus and Mild Cognitive Dysfunction in the Elderly.Biomedicines · 2023Article
- Detecting type 2 diabetes mellitus cognitive impairment using whole-brain functional connectivity.Scientific reports · 2023Article
- Risk of Neurodegenerative Diseases in Elderly Koreans with an Initial Diagnosis of Type 2 Diabetes: A Nationwide Retrospective Cohort Study.Journal of diabetes research · 2023Article
- T2DM patients with depression have higher levels of hyperglycemia and cognitive decline than T2DM patients.PloS one · 2022Article
- Type 2 diabetes is associated with increased risk of dementia, but not mild cognitive impairment: a cross-sectional study among the elderly in Chinese communities.Frontiers in aging neuroscience · 2022Article
- Predictors of Cognitive Function in Community-Dwelling Older Adults by Age Group: Based on the 2017 National Survey of Older Korean Adults.International journal of environmental research and public health · 2021Article
- Hemorrhagic stroke outcomes of KApSR patients with co-morbid diabetes and Alzheimer's disease.Annals of translational medicine · 2021Article
- Mitochondrial Dysfunction and Mitophagy Closely Cooperate in Neurological Deficits Associated with Alzheimer's Disease and Type 2 Diabetes.Molecular neurobiology · 2021Review
- Article
- Validation and psychometric properties of the self-efficacy for Appropriate Medication Use Scale in elderly Chinese patients.International journal of clinical pharmacy · 2021Article
- The Association between Olfactory Function and Cognitive Impairment in Older Persons with Cognitive Impairments: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2021Article
- O-GlcNAcylation as a Therapeutic Target for Alzheimer's Disease.Neuromolecular medicine · 2020Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMild cognitive impairment (MCI) is the prodromal stage of Alzheimer's disease (AD), so identification of the related risk factors can be helpful. Although the association between type 2 diabetes mellitus (T2DM) and these modest changes in cognition is well established, whether T2DM will promote the transformation of MCI into AD is not a unified conclusion.
objectiveThis study aims to explore the relationship between T2DM and MCI in the elderly population living in the community in Shanghai, People's Republic of China.
methodsA total of 197 participants were included in the study. They were screened for T2DM, hyperlipidemia, traumatic brain injury, and family history of dementia. The Mini-Mental State Examination and the Montreal Cognitive Assessment were used to assess cognitive function. The diagnosis of AD was made according to
resultsA total of 82 (41.6%) participants had no cognitive impairment, 82 (41.6%) participants had MCI, and 33 (16.8%) participants had AD. Multivariate logistic regression models demonstrated that T2DM was a risk factor for AD (odds ratio =49.723, 95% CI =21.173-111.987).
conclusionT2DM might be a risk factor for MCI progressing into AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.