Statins × cardiovascular events

Observational studyCardiovascular diabetology2016

Moderate-intensity statin therapy seems ineffective in primary cardiovascular prevention in patients with type 2 diabetes complicated by nephropathy. A multicenter prospective 8 years follow up study.

Ferdinando Carlo Sasso et al.PubMed ↗Full text ↗Publisher ↗

  • HbA1clooks bad hereHigher major heart events.Correlation only, not a test of it.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

HbA1c went with higher major heart events

+20%+4% to +39%

HbA1c

Bigger than 4 in 10 for cardiovascular events

As reported

HR 1.201, 95% CI 1.04–1.39 · the paper's word: MACE

Who was studied, and how

850people in the Nephropathy in Type 2 Diabetes trial, from 2005
564of them with cardiovascular disease, in this paper

Already taking HbA1c, or nottheir own situation, not assigned

on HbA1c
not on HbA1c

HbA1c went with higher major heart events+20%

correlation, not a test

the abstract, start to end

of MACE between the two groups (HR 1.201, CI 1.041-1.387, p 0.012).

← favours treatmentfavours comparator →
could be chance
MACEHbA1c
HR 1.2011.04–1.39
StatinsCardiovascular events
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10 papers cite it

2016
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this paperpooled ittrialcites it

The trial

Full record →Abstract, authors, funding and every citing paper · PMID 27733159