ArticleAtherosclerosis2016
Genetic analysis of atherosclerosis identifies a major susceptibility locus in the major histocompatibility complex of mice.
Article in Atherosclerosis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 14 citations in OpenAlex.
- The Genetic Elements of the Obesity Paradox in Atherosclerosis Identified in an Intercross Between Hyperlipidemic Mouse Strains.International journal of molecular sciences · 2025Article
- Identification of novel genes associated with atherosclerosis in Bama miniature pig.Animal models and experimental medicine · 2024Article
- Article
- Genetic Evidence for a Causal Relationship between Hyperlipidemia and Type 2 Diabetes in Mice.International journal of molecular sciences · 2022Article
- Genetic connection of carotid atherosclerosis with coat color and body weight in an intercross between hyperlipidemic mouse strains.Physiological genomics · 2022Article
- Genetic Connection between Hyperglycemia and Carotid Atherosclerosis in Hyperlipidemic Mice.Genes · 2022Article
- Article
- Regional Variation in Genetic Control of Atherosclerosis in Hyperlipidemic Mice.G3 (Bethesda, Md.) · 2020Article
- Data on genetic linkage of oxidative stress with cardiometabolic traits in an intercross derived from hyperlipidemic mouse strains.Data in brief · 2020Article
- Genetic linkage of oxidative stress with cardiometabolic traits in an intercross derived from hyperlipidemic mouse strains.Atherosclerosis · 2020Article
- A severe atherosclerosis mouse model on the resistant NOD background.Disease models & mechanisms · 2018Article
- Genetic analysis of a mouse cross implicates an anti-inflammatory gene in control of atherosclerosis susceptibility.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Polygenic Control of Carotid Atherosclerosis in a BALB/cJ × SM/J Intercross and a Combined Cross Involving Multiple Mouse Strains.G3 (Bethesda, Md.) · 2017Article
- Data on genetic analysis of atherosclerosis identifies a major susceptibility locus in the major histocompatibility complex of mice.Data in brief · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
aimsRecent genome-wide association studies (GWAS) have identified over 50 significant loci containing common variants associated with coronary artery disease. However, these variants explain only 26% of the genetic heritability of the disease, suggesting that many more variants remain to be discovered. Here, we examined the genetic basis underlying the marked difference between SM/J-Apoe
methods206 female F
resultsA significant locus, named Ath49 (LOD score: 4.18), for atherosclerosis was mapped to the H2 complex [mouse major histocompatibility complex (MHC)] on chromosome 17. Bioinformatic analysis identified 12 probable candidate genes, including Tnfrsf21, Adgrf1, Adgrf5, Mep1a, and Pla2g7. Corresponding human genomic regions of Ath49 showed significant association with coronary heart disease. Five suggestive loci on chromosomes 1, 4, 5, and 8 for atherosclerosis were also identified. Atherosclerotic lesion sizes were significantly correlated with HDL but not with non-HDL cholesterol, triglyceride or glucose levels in the F
conclusionsWe have identified the MHC as a major genetic determinant of atherosclerosis, highlighting the importance of inflammation in atherogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.