Trial reportScientific reports2016
Eating disinhibition and vagal tone moderate the postprandial response to glycemic load: a randomised controlled trial.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02827318 (Eating Disinhibition and Vagal Tone Moderate the Postprandial Response to Glycaemic Load), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Eating Disinhibition and Vagal Tone Moderate the Postprandial Response to Glycaemic Load: A Randomised Controlled Trial
Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Alignment of Consumers' Expected Brain Benefits from Food and Supplements with Measurable Cognitive Performance Tests.Nutrients · 2024Article
- Article
- Weaker connectivity in resting state networks is associated with disinhibited eating in older adults.International journal of obesity (2005) · 2022Article
- Individual differences in sensory and expectation driven interoceptive processes: a novel paradigm with implications for alexithymia, disordered eating and obesity.Scientific reports · 2021Article
- Autonomic adaptations mediate the effect of hydration on brain functioning and mood: Evidence from two randomized controlled trials.Scientific reports · 2019Article
- Interoceptive accuracy moderates the response to a glucose load: a test of the predictive coding framework.Proceedings. Biological sciences · 2019Article
- Glucose Activates Vagal Control of Hyperglycemia and Inflammation in Fasted Mice.Scientific reports · 2019Article
- Neurocognitive effects of umami: association with eating behavior and food choice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Heart-rate variability: a biomarker to study the influence of nutrition on physiological and psychological health?Behavioural pharmacology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reducing the glycemic load (GL) of the diet may benefit appetite control but its utility is complicated by psychological influences on eating. Disinhibited behaviour, a risk factor for overconsumption, is characterized by reduced prefrontal cortex activity, which in turn modulates vagal tone; a phenomenon associated with glucoregulation. This double blind randomised controlled trial explored for the first time the influence of disinhibited eating and vagal tone (heart rate variability (HRV)) on hunger and the postprandial response to GL. Blood glucose (BG) and hunger were measured 30 and 150 min after consumption of water, glucose or isomaltulose (low glycemic sugar). After consuming glucose, independently of BMI or habitual diet, those with the highest levels of disinhibition had higher BG levels after thirty minutes (B = 0.192, 95% CI LL. 086, UL 0.297), and lower BG after one hundred and fifty minutes (B = -0.240, 95% CI LL -0.348, UL -0.131). BG was related to hunger but only in low disinhibited eaters. Disinhibited eaters were characterised by a reduced HRV which was related to greater BG excursions (B = 0.407, 95% CI LL 0.044, UL 1.134). These findings highlight novel mechanisms by which disinhibited eating leads to obesity and insulin resistance. This trial was registered at clinicaltrials.gov NCT02827318.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.