Evidence map›Paper›PMID 27768209›Full record

ArticleThe journal of vascular access2016

Distinct impact of three different statins on arteriovenous fistula outcomes: a retrospective analysis.

Laisel Martinez, Juan C Duque, Luis A Escobar, Marwan Tabbara, Arif Asif, Fadi Fayad, Roberto I Vazquez-Padron, Loay H Salman

Registry-linked trialOpen access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of vascular access, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03188978 (High-intensity Atorvastatin for Arteriovenous Fistula Failure), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03188978 phase1 / phase2withdrawnnot on this mapstarted 2018, after this paper: background citation

High-intensity Atorvastatin for Arteriovenous Fistula Failure (HAFF): A Feasibility Pilot Study

TypeinterventionalSponsorAlbany Medical CollegeRan2018 to 2019Enrolled0ConditionsPrimary Arteriovenous Fistula FailureArmsAtorvastatin 40mg, Placebo
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Atorvastatin ReducesJournal of the American Society of Nephrology : JASN · 2020
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Laisel MartinezDeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida - USA.
Juan C DuqueDepartment of Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida - USA.
Luis A EscobarDeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida - USA.
Marwan TabbaraDeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida - USA.
Arif AsifDepartment of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, New Jersey - USA.
Fadi FayadSection of Interventional Nephrology, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida - USA.
Roberto I Vazquez-PadronDeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida - USA.
Loay H SalmanDivision of Nephrology and Hypertension, Albany Medical College, Albany, New York - USA.
University of Miami · USAlbany Medical Center Hospital · USHackensack Meridian Health · US

Funding

NIDDK NIH HHS R01 DK098511
6 · The paper itself

Abstract

purposeWhether statins improve arteriovenous fistula (AVF) outcomes is still a matter of debate. Taking into consideration the existing physicochemical differences between individual drugs, this study evaluates the impact of three different statins (atorvastatin, rosuvastatin and simvastatin) on one-stage and two-stage AVF outcomes.

methodsUsing a retrospective cohort of 535 patients, we analyzed the effects of each statin on primary failure and primary patency using multivariate logistic regressions and Cox proportional hazard models.

resultsOut of the three statins analyzed, only atorvastatin improved the overall primary failure of AVF (odds ratio [OR] = 0.18, p = 0.005). Comparisons between the two AVF types demonstrated that this effect was due to a prominent reduction in primary failure of one-stage (OR = 0.03; p = 0.005), but not two-stage fistulas (OR = 0.43; p = 0.25). In contrast, primary patency of two-stage (hazards ratio [HR] = 0.51; p = 0.024), but not one-stage fistulas (HR = 0.98; p = 0.95), was improved by all statins as a group, but not by individual drugs.

conclusionsOur results suggest that the potential benefit of statins on AVF outcomes is a drug-specific and not a class effect, and that such effect is also influenced by the type of fistula.

Indexed as

Arteriovenous Shunt, SurgicalAdultAgedAtorvastatinFemaleGraft Occlusion, VascularHumansHydroxymethylglutaryl-CoA Reductase InhibitorsKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioProportional Hazards ModelsRetrospective StudiesAtorvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsRosuvastatin CalciumSimvastatin

Identifiers

PMID27768209
PMCPMC10970648
OpenAlexW2538420949

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.