Evidence map›Paper›PMID 27776536›Full record

Trial reportTrials2016

Postprandial effect of breakfast glycaemic index on vascular function, glycaemic control and cognitive performance (BGI study): study protocol for a randomised crossover trial.

Natalia Sanchez-Aguadero, Luis Garcia-Ortiz, Maria C Patino-Alonso, Sara Mora-Simon, Manuel A Gomez-Marcos, Rosario Alonso-Dominguez, Benigna Sanchez-Salgado, Jose I Recio-Rodriguez

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02616276 (Postprandial Effect of Breakfast Glycemic Index on Vascular Function, Insulinemia and Cognitive Performance, a Crossover Clinical Trial), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02616276 nacompletednot on this map

Postprandial Effect of Breakfast Glycemic Index on Vascular Function, Insulinemia and Cognitive Performance, a Crossover Clinical Trial (BGI Study)

TypeinterventionalSponsorFundacion para la Investigacion y Formacion en Ciencias de la SaludRan2015 to 2017Enrolled40ConditionsHealthyArmsControl breakfast, High glycemic index breakfast, Low glycemic index breakfast
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Effect of cocoa on blood pressure.The Cochrane database of systematic reviews · 2017
    Pooled it
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Natalia Sanchez-AguaderoPrimary Care Research Unit, The Alamedilla Health Centre, Castilla and León Health Service (SACYL), Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain. natalia.san.ag@gmail.com.
Luis Garcia-OrtizPrimary Care Research Unit, The Alamedilla Health Centre, Castilla and León Health Service (SACYL), Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
Maria C Patino-AlonsoDepartment of Statistics, University of Salamanca, Salamanca, Spain.
Sara Mora-SimonPrimary Care Research Unit, The Alamedilla Health Centre, Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
Manuel A Gomez-MarcosPrimary Care Research Unit, The Alamedilla Health Centre, Castilla and León Health Service (SACYL), Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
Rosario Alonso-DominguezPrimary Care Research Unit, The Alamedilla Health Centre, Castilla and León Health Service (SACYL), Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
Benigna Sanchez-SalgadoPrimary Care Research Unit, The Alamedilla Health Centre, Castilla and León Health Service (SACYL), Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
Jose I Recio-RodriguezPrimary Care Research Unit, The Alamedilla Health Centre, Castilla and León Health Service (SACYL), Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostprandial glycaemic response affects cognitive and vascular function. The acute effect of breakfast glycaemic index on vascular parameters is not sufficiently known. Also, the influence of breakfasts with different glycaemic index on cognitive performance has been mostly studied in children and adolescents with varying results. Therefore, the purpose of this study is to analyse the postprandial effect of high and low glycaemic index breakfasts on vascular function and cognitive performance and their relationship with postprandial glycaemic response in healthy young adults. METHODS/

designThis is a crossover clinical trial targeting adults (aged 20-40 years, free from cardiovascular disease) selected by consecutive sampling at urban primary care health clinics in Salamanca (Spain). Each subject will complete three interventions with a washout period of one week: a control condition (consisting of water); a low glycaemic index breakfast (consisting of dark chocolate, walnuts, yogurt and an apple, with an overall glycaemic index of 29.4 and an energy contribution of 1489 kJ); and a high glycaemic index breakfast (consisting of bread, grape juice and strawberry jam, with an overall glycaemic index of 64.0 and an energy contribution of 1318 kJ). The postprandial effect will be assessed at 60 and 120 minutes from each breakfast including blood sampling and cognitive performance evaluations. Measurements of arterial stiffness and central haemodynamic parameters will be taken at -10, 0, 15, 30, 45, 60, 75, 90, 105 and 120 minutes. DISCUSSION: The differences in postprandial glycaemic response due to breakfast glycaemic index could affect vascular parameters and cognitive performance with important applications and implications for the general population. This could provide necessary information for the establishment of new strategies in terms of nutritional education and work performance improvement.

trial registrationClinicalTrials.gov:  NCT02616276 . Registered on 19 November 2015.

Indexed as

BreakfastCognitionGlycemic IndexHemodynamicsPostprandial PeriodVascular StiffnessAdultBiomarkersBlood GlucoseClinical ProtocolsCross-Over StudiesEnergy IntakeFemaleHumansMaleResearch DesignBiomarkersBlood GlucoseBlood glucoseCognitionGlycaemic indexPostprandial periodVascular stiffness

Identifiers

PMID27776536
PMCPMC5078881

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.