GLP-1 receptor agonists × cardiac & vascular function

TrialEuropean journal of heart failure2017

Effect of liraglutide, a glucagon-like peptide-1 analogue, on left ventricular function in stable chronic heart failure patients with and without diabetes (LIVE)-a multicentre, double-blind, randomised, placebo-controlled trial.

Anders Jorsal et al.PubMed ↗Publisher ↗

  • Liraglutide 1.8 mg once dailyno clear effectNo clear effect on LVEF, higher heart rate.Nothing cleared the noise.

What the trial testedas reported · 241 people · 2017

Range includes no effect

No clear effect on LVEF

−0.80percentage points−2.10 to +0.50

liraglutide 1.8 mg once daily vs matching placebo

As reported

difference −0.8 %, 95% CI −2.10 to 0.50 · the paper's word: Change in LVEF

Not counted

Probably raised heart rate

+7.00+5.00 to +9.00

liraglutide 1.8 mg once daily vs matching placebo

As reported

difference 7, 95% CI 5.00–9.00

Who was studied, and how

830people in the The Impact of Dietary Management Applet for Weight Reduction in Obese Heart Failure Patients trial, from 2024
241of them with cardiovascular disease, in this paper

The trial randomly assignedassigned by chance

liraglutide 1.8 mg once daily
matching placebo

No clear effect on LVEF−0.80

Probably raised heart rate+7.00

randomised

the abstract, start to end

difference (95% confidence interval) was -0.8% (-2.1, 0.5; P = 0.24).

with liraglutide [mean difference: 7 b.p.m.

← favours treatmentfavours comparator →
could be chance
Change in LVEFliraglutide 1.8 mg once daily vs matching placebo
−0.8−2.10 to 0.50
Heart rateliraglutide 1.8 mg once daily vs matching placebo
75.00–9.00
GLP-1 receptor agonistsCardiac & vascular functionAdverse events & safety

GLP-1 receptor agonists × cardiac & vascular functionhelps?mixed

unlikelylikely
0.500.50 without it
← favours comparatorfavours treatment →
this papermore certainless certain
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260 papers cite itlatest 60 shown

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this paperpooled ittrialcites it

The trial

Full record →Abstract, authors, funding and every citing paper · PMID 27790809