ArticlePhysiological reports2016
Muscle oxygenation during dynamic plantar flexion exercise: combining BOLD MRI with traditional physiological measurements.
Article in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Factors Influencing AMPK Activation During Cycling Exercise: A Pooled Analysis and Meta-Regression.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Effect of external pressure and muscle contraction on soft tissue oxygenation measured with near infrared spectroscopy.Bulletin of the Hospital for Joint Disease (2013) · 2026Article
- Radiological frontiers in understanding paraspinal muscle pathophysiology in chronic low back pain.Frontiers in medicine · 2025Review
- IVIM Imaging of Paraspinal Muscles Following Moderate and High-Intensity Exercise in Healthy Individuals.Frontiers in rehabilitation sciences · 2022Article
- Muscular blood oxygen level-dependent MRI is beneficial to evaluate effectiveness of an exercise prescription.Annals of translational medicine · 2021Article
- Assessment of lumbar paraspinal muscle activation using fMRI BOLD imaging and T2 mapping.Quantitative imaging in medicine and surgery · 2020Article
- The exercise pressor reflex and active OPhysiological reports · 2019Article
- Exercise-stimulated arterial transit time in calf muscles measured by dynamic contrast-enhanced magnetic resonance imaging.Physiological reports · 2019Article
- Dynamic characteristics of T2*-weighted signal in calf muscles of peripheral artery disease during low-intensity exercise.Journal of magnetic resonance imaging : JMRI · 2017Article
- Blood pressure and calf muscle oxygen extraction during plantar flexion exercise in peripheral artery disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Muscle oxygenation during dynamic plantar flexion exercise: combining BOLD MRI with traditional physiological measurements.Physiological reports · 2016Article
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Authors and funding
18 authors at 2 institutions in 1 country.
Funding
Abstract
Blood-oxygen-level-dependent magnetic resonance imaging (BOLD MRI) has the potential to quantify skeletal muscle oxygenation with high temporal and high spatial resolution. The purpose of this study was to characterize skeletal muscle BOLD responses during steady-state plantar flexion exercise (i.e., during the brief rest periods between muscle contraction). We used three different imaging modalities (ultrasound of the popliteal artery, BOLD MRI, and near-infrared spectroscopy [NIRS]) and two different exercise intensities (2 and 6 kg). Six healthy men underwent three separate protocols of dynamic plantar flexion exercise on separate days and acute physiological responses were measured. Ultrasound studies showed the percent change in popliteal velocity from baseline to the end of exercise was 151 ± 24% during 2 kg and 589 ± 145% during 6 kg. MRI studies showed an abrupt decrease in BOLD signal intensity at the onset of 2 kg exercise, indicating deoxygenation. The BOLD signal was further reduced during 6 kg exercise (compared to 2 kg) at 1 min (-4.3 ± 0.7 vs. -1.2 ± 0.4%, P < 0.001). Similarly, the change in the NIRS muscle oxygen saturation in the medial gastrocnemius was -11 ± 4% at 2 kg and -38 ± 11% with 6 kg (P = 0.041). In conclusion, we demonstrate that BOLD signal intensity decreases during plantar flexion and this effect is augmented at higher exercise workloads.
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Registered trials
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