Evidence map›Paper›PMID 27802149›Full record

ReviewThe Journal of experimental biology2016

Hemoglobin-oxygen affinity in high-altitude vertebrates: is there evidence for an adaptive trend?

Jay F Storz

Abstract readReview
In one paragraph

Review in The Journal of experimental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
11.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 139 citations in OpenAlex.

  1. Carboxyhemoglobin and depletion of blood oxygen in sleeping elephant seals.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Gas exchange, oxygen transport and metabolism in high-altitude waterfowl.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  6. Animals : an open access journal from MDPI · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Local adaptation, plasticity, and evolved resistance to hypoxic cold stress in high-altitude deer mice.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Exercise and Experiments of Nature.Comprehensive Physiology · 2023
    Article
  17. Article
  18. Article
  19. Hemoglobin Isoforms in Rat Erythrocytes in Acute Aseptic Inflammation.Bulletin of experimental biology and medicine · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Jay F StorzSchool of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA jstorz2@unl.edu.ORCID 0000-0001-5448-7924
University of Nebraska–Lincoln · US

Funding

Mutational Pleiotropy, Epistasis, and the Adaptive Evolution of Hemoglobin FunctionR01HL087216 · NHLBI · UNIVERSITY OF NEBRASKA LINCOLN · PI STORZ, JAY · 2008 to 2021
$4.5M
NHLBI NIH HHS R01 HL087216
6 · The paper itself

Abstract

In air-breathing vertebrates at high altitude, fine-tuned adjustments in hemoglobin (Hb)-O

Indexed as

Adaptation, PhysiologicalAltitudeAnimalsHemoglobinsHypoxiaOxygenVertebratesHemoglobinsOxygenBiochemical adaptationBlood oxygen transportHemoglobinHigh-altitude adaptationHypoxiaPhysiological adaptation

Identifiers

PMID27802149
PMCPMC5091379
OpenAlexW2538885384

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.