ArticleScientific reports2016
Fish gut-liver immunity during homeostasis or inflammation revealed by integrative transcriptome and proteome studies.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 117 citations in OpenAlex.
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- Comparative Intestinal Transcriptomics Reveals Sex-Dependent Physiological Signatures inAnimals : an open access journal from MDPI · 2026Article
- Integrated Multi-Omics Analysis Reveals the Physiological and Metabolic Response Mechanisms ofAnimals : an open access journal from MDPI · 2026Article
- Analysis of MHC class II-bound CyHV-2 peptides inJournal of virology · 2026Article
- Gut dysbiosis after successive administration of florfenicol-medicated feed alters intestinal inflammatory response and growth patterns in healthy Atlantic salmon (Salmo salar).Animal microbiome · 2025Article
- An Overview of Advancements in Proteomic Approaches to Enhance Livestock Production and Aquaculture.Animals : an open access journal from MDPI · 2025Review
- Glutathione Peroxidase 4 in Blunt Snout Bream (Current issues in molecular biology · 2025Article
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- Antibacterial activity of baicalein againstFrontiers in microbiology · 2025Article
- Glandular cell products in adult cestode: A new tale of tapeworm interaction with fish innate immune response.International journal for parasitology. Parasites and wildlife · 2024Article
- Effects of Dietary Fish Oil Supplementation on the Growth, Proximate Composition, and Liver Health of Chinese Stripe-Necked Turtle (Animals : an open access journal from MDPI · 2024Article
- Integrated time-series biochemical, transcriptomic, and metabolomic analyses reveal key metabolites and signaling pathways in the liver of the Chinese soft-shelled turtle (Frontiers in immunology · 2024Article
- The anti-inflammatory role of zDHHC23 through the promotion of macrophage M2 polarization and macrophage necroptosis in large yellow croaker (Frontiers in immunology · 2024Article
- Baicalin enhances antioxidant, inflammatory defense, and microbial diversity of yellow catfish (Frontiers in microbiology · 2024Article
- Long-Term Application of a Synbiotic Chitosan andMicroorganisms · 2023Article
- Article
- Allelically and Differentially Expressed Genes After Infection of Edwardsiella ictaluri in Channel Catfish as Determined by Bulk Segregant RNA-Seq.Marine biotechnology (New York, N.Y.) · 2022Article
- Dietary Inclusion of Seabuckthorn (Frontiers in physiology · 2022Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut-associated lymphoid tissue, connected with liver via bile and blood, constructs a local immune environment of both defense and tolerance. The gut-liver immunity has been well-studied in mammals, yet in fish remains largely unknown, even though enteritis as well as liver and gallbladder syndrome emerged as a limitation in aquaculture. In this study, we performed integrative bioinformatic analysis for both transcriptomic (gut and liver) and proteomic (intestinal mucus and bile) data, in both healthy and infected tilapias. We found more categories of immune transcripts in gut than liver, as well as more adaptive immune in gut meanwhile more innate in liver. Interestingly reduced differential immune transcripts between gut and liver upon inflammation were also revealed. In addition, more immune proteins in bile than intestinal mucus were identified. And bile probably providing immune effectors to intestinal mucus upon inflammation was deduced. Specifically, many key immune transcripts in gut or liver as well as key immune proteins in mucus or bile were demonstrated. Accordingly, we proposed a hypothesized profile of fish gut-liver immunity, during either homeostasis or inflammation. Current data suggested that fish gut and liver may collaborate immunologically while keep homeostasis using own strategies, including potential unique mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.