Evidence map›Paper›PMID 27824158›Full record

Trial reportScientific reports2016

Screening for diabetic retinopathy using new mydriasis-free, full-field flicker ERG recording device.

Motonobu Fukuo, Mineo Kondo, Akira Hirose, Harumi Fukushima, Kengo Ikesugi, Masahiko Sugimoto, Kumiko Kato, Yasuko Uchigata, Shigehiko Kitano

Abstract readClinical Trial
In one paragraph

Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Trial
  2. Article
  3. Intra- and inter-examiner reliability of ERGs recorded with two types of skin electrodes.Documenta ophthalmologica. Advances in ophthalmology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Measuring differences in the ERG in myopia using the RETeval device with skin electrodes.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
    Article
  12. Article
  13. Observational
  14. Article
  15. Article
  16. Electroretinographic Evaluations of Eyes With Endophthalmitis.Translational vision science & technology · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Motonobu FukuoDepartment of Diabetic Ophthalmology, Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan.
Mineo KondoDepartment of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan.
Akira HiroseDepartment of Diabetic Ophthalmology, Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan.
Harumi FukushimaDepartment of Diabetic Ophthalmology, Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan.
Kengo IkesugiDepartment of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan.
Masahiko SugimotoDepartment of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan.
Kumiko KatoDepartment of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan.
Yasuko UchigataDiabetes Center, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
Shigehiko KitanoDepartment of Diabetic Ophthalmology, Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic retinopathy (DR) is a leading cause of blindness among working-age adults. Therefore, it is important to detect DR accurately during mass screening. The purpose of this study was to determine whether a small, hand-held, mydriasis-free, full-field flicker electroretinographic (ERGs) device called RETeval can be used to screen for DR. To accomplish this, we recorded full-field flicker ERGs with this device from 48 normal eyes and 118 eyes with different severities of DR in patients with diabetes mellitus (DM). This system delivered a constant flash retinal luminance by adjusting the flash luminance that compensated for changes in the pupil size. Our results showed that there were significant correlations between the severity of DR and the implicit times (P < 0.001; r = 0.55) and the amplitudes (P = 0.001; r = -0.29). When the implicit time was used for the index, the area under the receiver operating characteristic curve was 0.84 for the detection of DR, and was 0.89 for the detection of DR requiring ophthalmic treatments. These results suggest that the implicit times of the flicker ERGs recorded by the small, mydryasis-free ERG system can be used as an adjunctive tool to screen for DR.

Indexed as

AdultDiabetic RetinopathyElectroretinographyFemaleHumansMaleMiddle AgedProspective StudiesRetina

Identifiers

PMID27824158
PMCPMC5100463

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.