ArticleStroke2016
Menopausal Hot Flashes and Carotid Intima Media Thickness Among Midlife Women.
Article in Stroke, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- A systematic review of heart rate variability and menopausal vasomotor symptoms.Physiological reports · 2026Pooled it
- Anxiety, depressive symptoms, and cardiac autonomic function in perimenopausal and postmenopausal women with hot flashes: a brief report.Menopause (New York, N.Y.) · 2018Trial
- Review
- Estradiol and memory circuitry in the postmenopause: Modification by APOE4.Research square · 2026Article
- Evidence of APOE4-related brain vulnerabilities in verbal memory systems in midlife women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Physical activity moderates the relationship between hot flashes and arterial wave reflection in perimenopausal females.Physiological reports · 2026Article
- Article
- Association Between Vasomotor Symptoms and Ischemic Stroke: A Case-Control Study.Brain and behavior · 2025Article
- Lifetime trauma exposure and accelerated epigenetic aging among midlife women.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- Neurokinin Antagonists to Treat Vasomotor Symptoms-Possible Implications for Long-Term Health and Disease.Journal of clinical medicine · 2025Article
- Everyday discrimination and subclinical indicators of stroke in midlife women.Journal of behavioral medicine · 2025Article
- Menopause is a Whole-Person Developmental Transition: An Overview of Menopause Information and Acupuncture Therapy Approaches to Symptom Management.Medical acupuncture · 2025Article
- Endogenous Estrogens and Brain Activation During Verbal Memory Encoding and Recognition in the Postmenopause.The Journal of clinical endocrinology and metabolism · 2025Article
- Menopausal Vasomotor Symptoms and Subclinical Atherosclerotic Cardiovascular Disease: A Population-Based Study.Journal of the American Heart Association · 2024Article
- Reproductive hormones in relation to white matter hyperintensity volumes among midlife women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Trauma and its implications for women's cardiovascular health during the menopause transition: Lessons from MsHeart/MsBrain and SWAN studies.Maturitas · 2024Review
- Menopausal vasomotor symptoms and plasma Alzheimer disease biomarkers.American journal of obstetrics and gynecology · 2024Article
- Vasomotor symptoms and cardiovascular health: findings from the SWAN and the MsHeart/MsBrain studies.Climacteric : the journal of the International Menopause Society · 2024Review
- Associations of endogenous estrogens, plasma Alzheimer's disease biomarkers, andFrontiers in aging neuroscience · 2024Article
- Carotid intima media thickness and white matter hyperintensity volume among midlife women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
background and purposeThere has been a longstanding interest in the role of menopause and its correlates in the development of cardiovascular disease (CVD) in women. Menopausal hot flashes are experienced by most midlife women; emerging data link hot flashes to CVD risk indicators. We tested whether hot flashes, measured via state-of-the-art physiologic methods, were associated with greater subclinical atherosclerosis as assessed by carotid ultrasound. We considered the role of CVD risk factors and estradiol concentrations in these associations.
methodsA total of 295 nonsmoking women free of clinical CVD underwent ambulatory physiologic hot flash assessments; a blood draw; and carotid ultrasound measurement of intima media thickness and plaque. Associations between hot flashes and subclinical atherosclerosis were tested in regression models controlling for CVD risk factors and estradiol.
resultsMore frequent physiologic hot flashes were associated with higher carotid intima media thickness (for each additional hot flash: β [SE]=0.004 [0.001]; P=0.0001; reported hot flash: β [SE]=0.008 [0.002]; P=0.002, multivariable) and plaque (eg, for each additional hot flash, odds ratio [95% confidence interval] plaque index ≥2=1.07 [1.003-1.14]; P=0.04, relative to no plaque, multivariable] among women reporting daily hot flashes; associations were not accounted for by CVD risk factors or by estradiol. Among women reporting hot flashes, hot flashes accounted for more variance in intima media thickness than most CVD risk factors.
conclusionsAmong women reporting daily hot flashes, frequent hot flashes may provide information about a woman's vascular status beyond standard CVD risk factors and estradiol. Frequent hot flashes may mark a vulnerable vascular phenotype among midlife women.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.