SGLT2 inhibitors × glycemic control

SynthesisPloS one2016

Benefits and Harms of Sodium-Glucose Co-Transporter 2 Inhibitors in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Heidi Storgaard et al.PubMed ↗Full text ↗Publisher ↗

  • SGLT2-ilooks good hereLower long-term blood sugar.Randomised, large.
  • Canagliflozinlooks good hereLower long-term blood sugar.Randomised, large.

What the trial testedrandomised · 9,154 people · 2016

Randomised vs placebo

Lowered long-term blood sugar

−0.69percentage points−0.75 to −0.62

SGLT2-i vs placebo

As reported

difference −0.69 %, 95% CI −0.75 to −0.62 · the paper's word: HbA1c

Randomised vs placebo

Lowered long-term blood sugar

−0.85percentage points−0.99 to −0.71

Canagliflozin vs placebo

As reported

difference −0.85 %, 95% CI −0.99 to −0.71 · the paper's word: HbA1c

Not counted

Lowered long-term blood sugar

−0.20percentage points−0.28 to −0.13

SGLT2-i vs OAD

As reported

difference −0.20 %, 95% CI −0.28 to −0.13 · the paper's word: HbA1c

Who was studied, and how

9,154people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

SGLT2-i
placebo

Lowered long-term blood sugar−0.69

randomised

The trial randomly assignedassigned by chance

Canagliflozin
placebo

Lowered long-term blood sugar−0.85

randomised

the abstract, start to end

compared with placebo (mean difference -0.69%, 95% confidence interval -0.75

with the largest reduction in HbA1c (-0.85%, -0.99% to -0.71%).

of SGLT2-i on HbA1c compared with OAD (-0.20%, -0.28 to -0.13%; moderate

← favours treatmentfavours comparator →
could be chance
HbA1cSGLT2-i vs placebo
−0.69−0.75 to −0.62
HbA1cCanagliflozin vs placebo
−0.85−0.99 to −0.71
HbA1cSGLT2-i vs OAD
−0.20−0.28 to −0.13
SGLT2 inhibitorsGlycemic control

SGLT2 inhibitors × glycemic controlhelps?replicated

unlikelylikely
0.92not counted
← favours treatmentfavours comparator →
more certainless certain
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