Evidence map›Paper›PMID 27837775›Full record

ReviewGastroenterology clinics of North America2016

The Gut Microbiota: The Gateway to Improved Metabolism.

Kristina B Martinez, Joseph F Pierre, Eugene B Chang

Abstract readReview
In one paragraph

Review in Gastroenterology clinics of North America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Murine Models of Obesity-Related Cancer Risk.Cancer prevention research (Philadelphia, Pa.) · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Fecal microbial transplants as investigative tools in cancer.American journal of physiology. Gastrointestinal and liver physiology · 2024
    Review
  9. Article
  10. Influence of the Microbiome Metagenomics and Epigenomics on Gastric Cancer.International journal of molecular sciences · 2022
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kristina B MartinezSection of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Joseph F PierreSection of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Eugene B ChangSection of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Knapp Center for Biomedical Discovery, University of Chicago, Room 9130, 900 East 57th Street, Chicago, IL 60637, USA. Electronic address: echang@medicine.bsd.uchicago.edu.

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI LIU, CAMBRIAN YANGSHAO · 1990 to 2025
$29.8M
Research Training in Digestive Health, Diseases, and NutritionT32DK007074 · NIDDK · UNIVERSITY OF CHICAGO · PI EUGENE B CHANG · 1986 to 2026
$11.3M
Dietary fat effects on gut microbes, host immune state and experimental colitisR01DK097268 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 2012 to 2016
$2.2M
Novel role and function of Paneth cell PYY in anti-fungal innate immunityF32DK105728 · NIDDK · UNIVERSITY OF CHICAGO · PI PIERRE, JOSEPH F · 2015 to 2015
$54k
NIDDK NIH HHS F32 DK105728NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK097268NIDDK NIH HHS T32 DK007074
6 · The paper itself

Abstract

Obesity is an emerging global epidemic with profound challenges to world health care economies and societies. Traditional approaches to fighting obesity have not shown promise in promoting a decline in obesity prevalence. The gut microbiota is becoming widely appreciated for its role in regulating metabolism and thus represents a target for new therapies to combat obesity and associated comorbidities. This article provides an overview of altered microbial community structure in obesity, dietary impact on the gut microbiota, host-microbe interactions contributing to the disease, and improvements in microbial assemblage after bariatric surgery and with therapies targeting the gut microbiome.

Indexed as

Bariatric SurgeryDietFecal Microbiota TransplantationGastrointestinal MicrobiomeHumansObesityPrebioticsProbioticsRisk FactorsPrebioticsBariatric surgeryEnteroendocrine hormonesLipid absorptionMetabolismMicrobiotaPrebioticsProbioticsSynbiotics

Identifiers

PMID27837775
PMCPMC5127273

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.