Evidence map›Paper›PMID 27844334›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2018

Polymorphism of SLC6A2 gene does not influence outcome of myocardial

Derk O Verschure, F Baas, Berthe L F van Eck-Smit, G Aernout Somsen, Hein J Verberne

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Standardization ofClinical and translational imaging · 2017
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Derk O VerschureDepartment of Nuclear Medicine, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands. d.o.verschure@amc.uva.nl.
F BaasDepartment of Genome Analysis, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Berthe L F van Eck-SmitDepartment of Nuclear Medicine, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands.
G Aernout SomsenCardiology Centers of the Netherlands, Amsterdam, The Netherlands.
Hein J VerberneDepartment of Nuclear Medicine, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands.
Academic Medical Center · NLUniversity of Amsterdam · NLAmsterdam University Medical Centers · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe NET, encoded by SLC6A2, is responsible for presynaptic NE-reuptake. MATERIALS AND

methodsForty-nine adults with stable CHF (age 66.5 ± 8.1 years, LVEF 22.3 ± 6.4) were enrolled. Fifteen minutes (early) and 4 hours (late) after administration of

resultsWe found 6 different SLC6A2 SNPs, although none were functional. LVEF was the only independent predictor for early (adjusted R

conclusionIn this specific CHF population polymorphism of SLC6A2 gene was not associated with any

Indexed as

3-IodobenzylguanidineRadionuclide ImagingAgedChronic DiseaseFemaleHeart FailureHumansIodine RadioisotopesMaleMiddle AgedNorepinephrine Plasma Membrane Transport ProteinsPolymorphism, GeneticRadiopharmaceuticalsStroke Volume3-IodobenzylguanidineIodine-123Iodine RadioisotopesNorepinephrine Plasma Membrane Transport ProteinsRadiopharmaceuticalsSLC6A2 protein, humanCardiac sympathetic activitynorepinephrine transporterplanar 123I-mIBG myocardial scintigraphypolymorphismSLC6A2 gene

Identifiers

PMID27844334
PMCPMC5966480
OpenAlexW2551135532

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.