Evidence map›Paper›PMID 27856437›Full record

ArticleAJNR. American journal of neuroradiology2017

Quantifying Intracranial Plaque Permeability with Dynamic Contrast-Enhanced MRI: A Pilot Study.

P Vakil, A H Elmokadem, F H Syed, C G Cantrell, F H Dehkordi, T J Carroll, S A Ansari

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05907629 (Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05907629 recruitingnot on this mapstarted 2024, after this paper: background citation

Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

TypeobservationalSponsorYale UniversityRan2024 to 2029Enrolled300ConditionsStroke, Intracranial Atherosclerotic Stenosis (ICAS)ArmsMRI
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Vessel Wall Imaging of Intracranial Arteries: Fundamentals and Clinical Applications.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2023
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

P VakilFrom the College of Medicine (P.V.), University of Illinois, Chicago, Illinois.ORCID 0000-0002-3862-2185
A H ElmokademDepartments of Radiology (P.V., A.H.E., F.S., C.G.C., T.J.C., S.A.A.).ORCID 0000-0001-5119-9548
F H SyedDepartments of Radiology (P.V., A.H.E., F.S., C.G.C., T.J.C., S.A.A.).ORCID 0000-0002-9048-2538
C G CantrellDepartments of Radiology (P.V., A.H.E., F.S., C.G.C., T.J.C., S.A.A.).ORCID 0000-0003-0559-8681
F H DehkordiDepartment of Economics and Decision Sciences (F.H.D.), Western Illinois University, Macomb, Illinois.ORCID 0000-0002-0990-2436
T J CarrollDepartments of Radiology (P.V., A.H.E., F.S., C.G.C., T.J.C., S.A.A.).ORCID 0000-0002-5149-8377
S A AnsariDepartments of Radiology (P.V., A.H.E., F.S., C.G.C., T.J.C., S.A.A.) s-ansari@northwestern.edu.ORCID 0000-0001-8176-4616
Anna Needs Neuroblastoma Answers · USDr. C. V. Raman University · INNorthwestern University · USUniversity of Illinois Urbana-Champaign · USWestern Illinois University · US

Funding

Development of Novel MR Imaging for Ischemic Stroke EvaluationR01NS093908 · NINDS · UNIVERSITY OF CHICAGO · PI CARROLL, TIMOTHY J, CHRISTOFORIDIS, GREGORY · 2015 to 2019
$2.6M
High Resolution and Functional MRI Assessment of Intracranial Atherosclerotic PlaqueR21HL130969 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ANSARI, SAMEER A · 2016 to 2017
$425k
Development of MRI-based Cerebral Oxygen Extraction FractionR21EB017928 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CARROLL, TIMOTHY J · 2014 to 2015
$424k
NHLBI NIH HHS R21 HL130969NIBIB NIH HHS R21 EB017928NINDS NIH HHS R01 NS093908
6 · The paper itself

Abstract

background and purposeIntracranial atherosclerotic disease plaque hyperintensity and/or gadolinium contrast enhancement have been studied as imaging biomarkers of acutely symptomatic ischemic presentations using single static MR imaging measurements. However, the value in modeling the dynamics of intracranial plaque permeability has yet to be evaluated. The purpose of this study was to use dynamic contrast-enhanced MR imaging to quantify the contrast permeability of intracranial atherosclerotic disease plaques in symptomatic patients and to compare these parameters against existing markers of plaque volatility using black-blood MR imaging pulse sequences. MATERIALS AND

methodsWe performed a prospective study of contrast uptake dynamics in the major intracranial vessels proximal and immediately distal to the circle of Willis using dynamic contrast-enhanced MR imaging, specifically in patients with symptomatic intracranial atherosclerotic disease. Using the Modified Tofts model, we extracted the volume transfer constant (

resultsWe completed analysis in 10 patients presenting with symptomatic intracranial atherosclerotic disease.

conclusionsElevated

Indexed as

AdultAgedContrast MediaFemaleGadoliniumHumansIntracranial ArteriosclerosisMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingPermeabilityPilot ProjectsPlaque, AtheroscleroticProspective StudiesRisk FactorsContrast MediaGadolinium

Identifiers

PMID27856437
PMCPMC5309164
OpenAlexW2555518841

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.