Trial reportJournal of hypertension2017
The antihypertensive effects of aerobic versus isometric handgrip resistance exercise.
Trial report in Journal of hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06282302 (Effect of Isometric and Aerobic Physical Exercise on Blood Pressure Levels in Hypertensive Elderly People), which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Isometric and Aerobic Physical Exercise on Blood Pressure Levels in Hypertensive Elderly People: Randomized Clinical Trial
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Can postexercise hypotension also be observed in African and Asian populations: a systematic review and meta-analysis of randomized controlled trials.Journal of human hypertension · 2023Pooled it
- Evaluating the Methodological Quality of Postexercise Hypotension Aerobic Exercise Interventions.Frontiers in physiology · 2022Pooled it
- Resting blood pressure reductions following handgrip exercise training and the impact of age and sex: a systematic review and narrative synthesis.Systematic reviews · 2018Pooled it
- Trial
- Post-isometric exercise hypotension occurs irrespective of muscle mass in adults with hypertension: A randomized clinical trial.Clinics (Sao Paulo, Brazil) · 2025Trial
- Ventilatory Muscle Training for Early Cardiac Rehabilitation Improved Functional Capacity and Modulated Vascular Function of Individuals Undergoing Coronary Artery Bypass Grafting: Pilot Randomized Clinical Trial.International journal of environmental research and public health · 2022Trial
- Effect of Combined Endurance Training and MitoQ on Cardiac Function and Serum Level of Antioxidants, NO, miR-126, and miR-27a in Hypertensive Individuals.BioMed research international · 2022Trial
- Aerobic exercise, but not isometric handgrip exercise, improves endothelial function and arterial stiffness in patients with myocardial infarction undergoing coronary intervention: a randomized pilot study.BMC cardiovascular disorders · 2021Trial
- Salt Loading Blunts Central and Peripheral Postexercise Hypotension.Medicine and science in sports and exercise · 2020Trial
- Acute antihypertensive effect of self-selected exercise intensity in older women with hypertension: a crossover trial.Clinical interventions in aging · 2019Trial
- Acute blood pressure responses after different isometric handgrip protocols in hypertensive patients.Clinics (Sao Paulo, Brazil) · 2018Trial
- Rethinking Isometric Handgrip Exercise Prescription: A Commentary on Duration, Fatigue, and Blood Pressure Management.Health science reports · 2026Article
- Effects of the Intensity, Duration, and Muscle Mass of Isometric Handgrip Exercise on Neuromuscular Fatigue and Post-Exercise Blood Pressure Responses: A Crossover Study.Health science reports · 2026Article
- Validation of a novel multi-exercise approach to isometric resistance training in normotensive adults.European journal of applied physiology · 2025Article
- Post-Exercise Hypotension Induced by a Short Isometric Exercise Session Versus Combined Exercise in Hypertensive Patients with Ischemic Heart Disease: A Pilot Study.Journal of functional morphology and kinesiology · 2025Article
- Time course of cardiovascular responses to acute sustained handgrip exercise in young physically active men.Physiological reports · 2025Article
- Association between handgrip strength and hypertension in children and adolescents: an analysis of the National Health and Nutrition Examination Survey 2011-2014.Frontiers in pediatrics · 2025Article
- Isometric Exercise Training and Arterial Hypertension: An Updated Review.Sports medicine (Auckland, N.Z.) · 2024Review
- Criterion-Referenced Standards of Handgrip Strength for Identifying the Presence of Hypertension in Croatian Older Adults.Journal of clinical medicine · 2023Article
- Isometric handgrip exercise impacts only on very short-term blood pressure variability, but not on short-term blood pressure variability in hypertensive individuals: A randomized controlled trial.Frontiers in physiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundAerobic exercise reduces blood pressure (BP) on average 5-7 mmHg among those with hypertension; limited evidence suggests similar or even greater BP benefits may result from isometric handgrip (IHG) resistance exercise.
methodWe conducted a randomized controlled trial investigating the antihypertensive effects of an acute bout of aerobic compared with IHG exercise in the same individuals. Middle-aged adults (n = 27) with prehypertension and obesity randomly completed three experiments: aerobic (60% peak oxygen uptake, 30 min); IHG (30% maximum voluntary contraction, 4 × 2 min bilateral); and nonexercise control. Study participants were assessed for carotid-femoral pulse wave velocity pre and post exercise, and left the laboratory wearing an ambulatory BP monitor.
resultsSBP and DBP were lower after aerobic versus IHG (4.8 ± 1.8/3.1 ± 1.3 mmHg, P = 0.01/0.04) and control (5.6 ± 1.8/3.6 ± 1.3 mmHg, P = 0.02/0.04) over the awake hours, with no difference between IHG versus control (P = 0.80/0.83). Pulse wave velocity changes following acute exercise did not differ by modality (aerobic increased 0.01 ± 0.21 ms, IHG decreased 0.06 ± 0.15 ms, control increased 0.25 ± 0.17 ms, P > 0.05). A subset of participants then completed either 8 weeks of aerobic or IHG training. Awake SBP was lower after versus before aerobic training (7.6 ± 3.1 mmHg, P = 0.02), whereas sleep DBP was higher after IHG training (7.7 ± 2.3 mmHg, P = 0.02).
conclusionOur findings did not support IHG as antihypertensive therapy but that aerobic exercise should continue to be recommended as the primary exercise modality for its immediate and sustained BP benefits.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.