ArticleeLife2016
An NMDA receptor-dependent mechanism for subcellular segregation of sensory inputs in the tadpole optic tectum.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Assessing circuit function in the developingFrontiers in behavioral neuroscience · 2026Review
- Characterization of NaLife science alliance · 2024Article
- The effects of the NMDAR co-agonist D-serine on the structure and function of optic tectal neurons in the developing visual system.Scientific reports · 2023Article
- Article
- Positive Modulation of SK Channel Impedes Neuron-Specific Cytoskeletal Organization and Maturation.Developmental neuroscience · 2020Article
- Presenilin Regulates Retinotectal Synapse Formation through EphB2 Receptor Processing.Developmental neurobiology · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In the vertebrate CNS, afferent sensory inputs are targeted to specific depths or layers of their target neuropil. This patterning exists ab initio, from the very beginning, and therefore has been considered an activity-independent process. However, here we report that, during circuit development, the subcellular segregation of the visual and mechanosensory inputs to specific regions of tectal neuron dendrites in the tadpole optic tectum requires NMDA receptor activity. Blocking NMDARs during the formation of these sensory circuits, or removing the visual set of inputs, leads to less defined segregation, and suggests a correlation-based mechanism in which correlated inputs wire to common regions of dendrites. This can account for how two sets of inputs form synapses onto different regions of the same dendrite. Blocking NMDA receptors during later stages of circuit development did not disrupt segregation, indicating a critical period for activity-dependent shaping of patterns of innervation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.