Evidence map›Paper›PMID 27895421›Full record

ArticleWorld journal of gastroenterology2016

Carbon monoxide contributes to the constipating effects of granisetron in rat colon.

Carmela Nacci, Margherita Fanelli, Maria Assunta Potenza, Valentina Leo, Monica Montagnani, Maria Antonietta De Salvia

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Preclinical Studies to Evaluate the Gut Stimulatory Activity ofEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Carmela NacciCarmela Nacci, Maria Assunta Potenza, Valentina Leo, Monica Montagnani, Maria Antonietta De Salvia, Department of Biomedical Sciences and Human Oncology - Pharmacology Section, Medical School, University of Bari "Aldo Moro", Piazza G. Cesare, 70124 Bari, Italy.
Margherita FanelliCarmela Nacci, Maria Assunta Potenza, Valentina Leo, Monica Montagnani, Maria Antonietta De Salvia, Department of Biomedical Sciences and Human Oncology - Pharmacology Section, Medical School, University of Bari "Aldo Moro", Piazza G. Cesare, 70124 Bari, Italy.
Maria Assunta PotenzaCarmela Nacci, Maria Assunta Potenza, Valentina Leo, Monica Montagnani, Maria Antonietta De Salvia, Department of Biomedical Sciences and Human Oncology - Pharmacology Section, Medical School, University of Bari "Aldo Moro", Piazza G. Cesare, 70124 Bari, Italy.
Valentina LeoCarmela Nacci, Maria Assunta Potenza, Valentina Leo, Monica Montagnani, Maria Antonietta De Salvia, Department of Biomedical Sciences and Human Oncology - Pharmacology Section, Medical School, University of Bari "Aldo Moro", Piazza G. Cesare, 70124 Bari, Italy.
Monica MontagnaniCarmela Nacci, Maria Assunta Potenza, Valentina Leo, Monica Montagnani, Maria Antonietta De Salvia, Department of Biomedical Sciences and Human Oncology - Pharmacology Section, Medical School, University of Bari "Aldo Moro", Piazza G. Cesare, 70124 Bari, Italy.
Maria Antonietta De SalviaCarmela Nacci, Maria Assunta Potenza, Valentina Leo, Monica Montagnani, Maria Antonietta De Salvia, Department of Biomedical Sciences and Human Oncology - Pharmacology Section, Medical School, University of Bari "Aldo Moro", Piazza G. Cesare, 70124 Bari, Italy.
Creative Research Enterprises (United States) · USMayo Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the mechanisms underlying the potential contribution of the heme oxygenase/carbon monoxide (HO/CO) pathway in the constipating effects of granisetron.

methodsFor

resultsAdministration of granisetron (50, 75 μg/kg)

conclusionTaken together, findings from

Indexed as

AcetylcholineAnimalsCarbon MonoxideColonConstipationDefecationDose-Response Relationship, DrugElectric StimulationGastrointestinal MotilityGranisetronHeme Oxygenase (Decyclizing)HeminIn Vitro TechniquesMaleOrganometallic CompoundsProtoporphyrinsAcetylcholineCarbon MonoxideGranisetronHeme Oxygenase (Decyclizing)HeminOrganometallic CompoundsProtoporphyrinsSerotonin Antagoniststricarbonylchloro(glycinato)ruthenium(II)zinc protoporphyrinCarbon monoxideColonContractionGranisetronHeme oxygenaseMyogenic responseNeurogenic response

Identifiers

PMID27895421
PMCPMC5107697
OpenAlexW2552845046

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.